吉林大学学报(医学版) ›› 2020, Vol. 46 ›› Issue (6): 1293-1297.doi: 10.13481/j.1671-587x.20200629

• 临床研究 • 上一篇    下一篇

毛细支气管炎患儿血清TGF-β1水平与病情严重程度及肺功能指标的关联性分析

刘翔腾1,王桂兰1,2(),容嘉妍1,黄娟1,林嘉镖1,黄东明1,王冰洁1   

  1. 1.南方医科大学附属中山博爱医院小儿呼吸科,广东 中山 528403
    2.南方医科大学第二临床医学院儿科,广东 广州 510280
  • 收稿日期:2020-04-29 出版日期:2020-11-28 发布日期:2022-08-24
  • 通讯作者: 王桂兰 E-mail:13924973891@139.com
  • 作者简介:刘翔腾(1983-),男,广东省中山市人,副主任医师,主要从事小儿呼吸系统疾病诊治和儿童肺功能检测方面的研究。
  • 基金资助:
    广东省卫健委医学科研基金资助课题(A2020566);广东省中山市科技局社会公益科技研究专项基金资助课题(2017B1003)

Analysis on correlations between serum level of TGF-β1 and severity of bronchiolitis and pulmonary function indexes

Xiangteng LIU1,Guilan WANG1,2(),Jiayan RONG1,Juan HUANG1,Jiabiao LIN1,Dongming HUANG1,Bingjie WANG1   

  1. 1.Department of Children Respiratory,Affiliated Zhongshan Boai Hospital,Southern Medical University,Zhongshan 528403,China
    2.Department of Pediatrics,Second School of Clinical Medical Sciences,Southern Medical University,Guanzhou 510280,China
  • Received:2020-04-29 Online:2020-11-28 Published:2022-08-24
  • Contact: Guilan WANG E-mail:13924973891@139.com

摘要: 目的

探讨不同严重程度毛细支气管炎患儿血清转化生长因子β1(TGF-β1)水平及其与潮气呼吸肺功能指标的关联性,阐明TGF-β1水平在毛细支气管炎诊疗中的意义。

方法

选取84 例毛细支气管炎患儿作为毛细支气管炎组,按病情严重程度分为轻度毛细支气管炎组(n=46)和中重度毛细支气管炎组(n=38),另以同期行体检的健康婴幼儿20人作为正常对照组。分别检测急性期毛细支气管炎患儿、恢复期毛细支气管炎患儿及正常对照婴幼儿血清TGF-β1水平及潮气呼吸肺功能指标,采用Pearson相关分析法分析血清TGF-β1水平与潮气呼吸肺功能指标的相关性。

结果

急性期轻度毛细支气管炎组和中重度毛细支气管炎组患儿血清TGF-β1水平均明显高于正常对照组(P<0.01);与急性期轻度毛细支气管炎组比较,急性期中重度毛细支气管炎组患儿血清TGF-β1水平升高(P<0.01);与急性期比较,恢复期轻度和中重度毛细支气管炎组患儿血清TGF-β1 水平均明显降低(P<0.01)。轻度和中重度毛细支气管炎组患儿达峰时间比(TPTEF/TE)及达峰容积比(VPEF/VE)均明显低于正常对照组(P<0.05);与轻度毛细支气管炎组比较,中重度毛细支气管炎组患儿TPTEF/TE和VPEF/VE明显降低(P<0.05)。3组研究对象每公斤体重潮气量(VT/kg)比较差异无统计学意义(P>0.05)。毛细支气管炎组患儿血清TGF-β1与TPTEF/TE及VPEF/VE均呈负相关关系(r =-0.552,P<0.01;r =-0.517,P <0.01)。

结论

毛细支气管炎患儿血清TGF-β1水平能间接反映患儿的气道阻塞程度,可作为毛细支气管炎病情判断及肺功能预后评估的参考指标。

关键词: 毛细支气管炎, 转化生长因子β1, 潮气呼吸肺功能, 血清, 潮气量

Abstract: Objective

To investigate the levels of serum transformed growth factor beta 1 (TGF-β1) in the bronchiolitis pediatric patients with different severities and its correlations with the indexes of tidal breathing pulmonary function,and to discuss the significance of TGF-β1in the diagnosis and treatment of bronchiolitis.

Methods

A total of 84 cases of pediatric patients with bronchiolitis were selected as bronchiolitis group, and they were divided into mild bronchiolitis group (n=46) and moderate-severe bronchiolitis group (n=38) according to the severity of the disease.Another 20 healthy infants who underwent physical examination at the same time were selected as healthy control group.The levels of serum TGF-β1 and the ridal breathing pulmonary function indexes of the pediatric patients at acute and convalescent phases and the subjects in healthy control group were detected, and Pearson correlation analysis was used to analyze the correlations between the serum level of TGF-β1and the tidal breathing pulmonary function indexes.

Results

The serum levels of TGF-β1 of the pediatric patients in mild bronchitis group and moderate-severe bronchiolitis group at acute phase were significantly higher than those in healthy control group (P<0.01). Compared with mild bronchitis group, the serum TGF-β1 level of the pediatric patients in moderate -severe bronchiolitis group at acute stage was significantly increased (P<0.01). Compared with acute stage, the serum TGF-β1levels of the pediatric patients in mild and moderate-severe bronchiolitis groups at convalescence stage were significantly decreased (P<0.01). The TPTEF/TE and VPEF/VE of the pediatric patients in mild and moderate- severe bronchiolitis groups were significantly lower than those in healthy control group (P<0.05). Compared with mild bronchiolitis group, the TPTEF/TE and VPEF/VE of the pediatric patients in moderate-severe bronchiolitis group were significantly decreased (P<0.05). There was no significant difference in the tidal volume per kilogram of body weight among the subjects in three groups (P>0.05).The serum level of TGF-β1 of the bronchiolitis pediatric patients was negatively correlated with TPTEF/TE and VPEF/VE (r=-0.552, P<0.01; r=-0.517,P<0.01).

Conclusion

The serum level of TGF-β1 in the bronchiolitis pediatric patients can indirectly reflect the degree of airway obstruction, which can be used as a reference indicator for the condition judgment of bronchiolitis and the prognosis evaluation of lung function.

Key words: bronchiolitis, transforming growth factor-β1, tidal breathing pulmonary function, tidal volume

中图分类号: 

  • R722.135