关键词: jun, 口腔黏膜癌前损害, 口腔鳞状细胞癌, 免疫组织化学

Abstract: Abstract:Objective To investigate the expression of c-jun in precancerous lesion and squamous cell carcinoma tissues of hamster buckle pouch mucosa.Methods The models of premalignant and malignant lesions were established in hamster buckle pouch mucosa induced with DMBA.The expressions of c-jun in 23 oral normal mucosa, abnormal epithelial hyperplasia and 29 oral squamous cell carcinoma (OSCC) were measured with immunohistochemical SABC method.Results c-jun mainly expressed in basal cells and prickle cells in normal mucosa,simple and abnormal epithelial hyperplasia,its positive expression was in nucleus.c-jun expressed mainly in various layer cells of OSCC,its positive expression was in nucleus and cytoplasm.There were significant differences of positive expression rate between various groups(χ²=13.71，P<0.01).The positive expression rates in abnormal epithelial hyperplasia(77.2%) and OSCC(55.17%)were higher than that in normal mucosa(26.09%)(P<0.05).The positive expreesion rate in abnomal epithelral hyperlasia was higher than that in simple epithelial hyperlasina(36.36%)(P<0.05). Conclusion c-jun may play an important role in malignant transformation of oral benign lesions.

Key words: jun , oral premalignant lesions, oral squamous cell carcinoma, immunohistochemistry