EGFR及TGF-α在前列腺腺癌及前列腺上皮内瘤组织中的表达及其临床意义

J4 ›› 2012, Vol. 38 ›› Issue (2): 308-311.

EGFR及TGF-α在前列腺腺癌及前列腺上皮内瘤组织中的表达及其临床意义

王利群¹| 徐冶²|金仁顺^3

1.吉林医药学院护理学院急救社区护理学教研室|吉林吉林 132013；2.吉林医药学院医学科研实验室,吉林吉林 132013；3.延边大学附属医院病理科|吉林延边 133000

收稿日期:2011-10-28 出版日期:2012-03-28 发布日期:2012-03-28
通讯作者:  金仁顺（Tel：0433-2660121，E-mail: rsjin@163.com） E-mail:rsjin@163.com
作者简介:王利群（1965-）|女|吉林省吉林市人|副教授|医学硕士|主要从事护理教育与护理研究。

Expressions |of EGFR and TGF-α |in prostatic adenocarcinoma and prostatic intraepithelial neoplasia tissues and their clinical significances

WANG Li-qun¹| XU |Ye²|JIN Ren-shun³

1.Department of Emergency/Community Nursing,Nursing College|Jilin Medical College|Jilin 132013,China;2.Department of Medical Research Laboratory,Jilin Medical College,Jilin 132013,China；3. Department of Pathology|Affiliated Hospital| Yanbian University|Yanji 133000,China

Received:2011-10-28 Online:2012-03-28 Published:2012-03-28
Supported by:
吉林省科技厅自然科学基金项目资助课题（201015240）

摘要/Abstract

摘要：

目的: 探讨表皮生长因子受体（EGFR）和转化生长因子α（TGF-α）蛋白在前列腺腺癌（PAC）和高级别前列腺上皮内瘤(HGPIN)以及癌旁前列腺良性增生(BPH)组织中的表达，阐明其表达在PAC发生过程中的作用。方法: 收集41例PAC和癌旁BPH组织以及32例HGPIN病变组织，采用免疫组化SABC方法检测EGFR和TGF-α在不同病变中的表达。结果: ①EGFR在PAC、HGPIN及BPH组织中的阳性表达率分别为56.6%、53.7%及85.4%，在BPH中的表达率高于PAC和HGPIN，差异有统计学意义（P<0.01）。PAC和HGPIN组织中EGFR的表达差异无统计学意义(P>0.05)。EGFR的表达与肿瘤细胞的分化程度无关，在高、中和低分化PAC组织中阳性表达率分别为53.9%、55.6%及52.6%，差异无统计学意义（P>0.05）。②TGF-α在PAC中的阳性表达率为56.1%，在癌旁BPH组织中阳性表达率为85.4%，差异有统计学意义（P<0.01），但与肿瘤细胞的分化程度无关，在高、中和低分化PAC阳性表达率分别为53.8%、66.7%及52.6%，差异无统计学意义（P>0.05）。③TGF-α在HGPIN病变中的阳性表达率为56.3%，与PAC比较差异无统计学意义(P>0.05)，但与BPH比较差异有统计学意义（P<0.01）。EGFR和TGF-α在PAC中共同阳性率为81.8%，分别阳性率EGFR为18.2%，TGF-α为26.3%，两者呈正相关（r=0.558，P<0.001），但在HGPIN病变（r=0.111，P=5.450）和BPH（r=0.024，P=0.883）中两者无相关性。结论: EFFR和TGF-α蛋白在PAC、HGPIN和BPH组织中的表达水平不同，可以作为良恶性前列腺疾病的诊断及鉴别诊断指标，两者的表达在PAC发生过程中起到一定的作用。

关键词: 前列腺肿瘤；前列腺上皮内瘤；表皮生长因子受体；转化生长因子α

Abstract:

Objective
To study the expressions of epidermal growth factor (EGFR) and transforming growth factor-α(TGF-α) in human prostatic adenocarcinoma (PAC),high grade prostate intraepithelial neoplasia (HGPIN) and benign prostatic hyperplasia (BPH) tissues,and to explain the effect of the expressions in the development of PAC.Methods 41 specimens of PAC and specimens of BPH and 32 specimens of HGPIN were selected,the expressions of EGFR and TGF-α were determined by immuohistochemisitry staining.The relationship between the expressions of EGFR and TGF-α and histopathologic classification was analyzed.Results ①The EGFR positive rates were 56.6%,53.7% and 85.4% in PAC,HGPIN and BPH，the differences between BPH and HGPIN,BPH and PAC were statistically significant（P<0.01）. There was no significant difference in EGFR positive rate between PAC and HGPIN. The EGFR positive rates were 53.9%,55.6% and 52.6% in well-differentiated,moderately differentiated and poorly differentiated PAC,the expressions of EGFR had no correlation with different Gleason grades in PAC （P>0.05）.②The TGF-α positive rates in PAC and BPH were 56.1% and 85.4%,there was significant difference between them（P<0.01）.The TGF-α positive rate were 53.8%,66.7% and 52.6% in well differentiated,moderately differentiated and poorly differentiated PAC,the expressions of TGF-α had no correlation with different Gleason grades in PAC （P>0.01）. The TGF-α positive rate in HGPIN was 56.3%,there was no significant difference compared with PAC（P>0.05）,but there was significant difference compared with BPH (P<0.01).The collective positive rate of EGFR and TGF-α was 81.8%,the respective positive rate of EGFR was 18.2% and the respective positive rate of TGF-α was 26.3% in PAC,they had positive correlation（r=0.558，P<0.001） and they had no correlation in HGPIN （r=0.111，P=5.450） and BPH （r=0.024,P=0.883）. Conclusion The EGFR and TGF-α expression levels in PAC,HGPIN and BPH are different,combined detection of them can be useful for the diagnosis,differential diagnosis and evaluation in benign and malignant prostate disease.The expressions of EGFR and TGF-α play centain roles in the pathogenesis of prostatic adenocarcinoma．

Key words: prostatic neoplasms；high grade prostate intraepithelial neoplasia；epidermal growth factor；transforming growth factor-α

中图分类号:

王利群| 徐冶|金仁顺. EGFR及TGF-α在前列腺腺癌及前列腺上皮内瘤组织中的表达及其临床意义[J]. J4, 2012, 38(2): 308-311.

WANG Li-qun| XU Ye|JIN Ren-shun. Expressions |of EGFR and TGF-α |in prostatic adenocarcinoma and prostatic intraepithelial neoplasia tissues and their clinical significances[J]. J4, 2012, 38(2): 308-311.

[1]	周颖,高孟飞,朱慧勇. 间充质干细胞干性维持信号通路的研究进展[J]. 吉林大学学报(医学版), 2013, 39(3): 638-642.
[2]	李红，陈永浩，龚红君. 右美托咪定对肾癌根治术患者围术期炎性细胞因子和肾功能的影响[J]. 吉林大学学报(医学版), 2013, 39(3): 588-591.
[3]	李海波，刘行，孙美花,梁建民. 孕期至幼年期低水平铅暴露仔鼠海马锌离子平衡的变化及其发育期海马神经元的损伤[J]. 吉林大学学报(医学版), 2013, 39(3): 521-528.
[4]	谢波，沈梅，叶文鑫，舒彦，梁臻，张心男. 依帕司他联合行为疗法治疗女性糖尿病膀胱的临床疗效评价[J]. 吉林大学学报(医学版), 2013, 39(3): 597-600.
[5]	李辉,赵丽晶,杜宇,杨铁铮，李国峰,陈亮,支晨阳,李娜,周建华. 结肠安栓联合舒血宁对溃疡性结肠炎大鼠的治疗作用及其机制[J]. 吉林大学学报(医学版), 2013, 39(3): 488-493.
[6]	张洪长，王恩鹏，陈新，唐燕，王洪鑫，王炫策，许新. 人参皂苷Re对UVC辐射损伤细胞的保护作用[J]. 吉林大学学报(医学版), 2013, 39(3): 507-511.
[7]	武国东，王素侠，及志勇，张舒岩. 急性心力衰竭大鼠B型钠尿肽水平与肝功能的关系[J]. 吉林大学学报(医学版), 2013, 39(3): 517-520.
[8]	陈宣男，全首祯. NDM1基因常规PCR与荧光定量PCR检测方法的建立及其检测结果比较[J]. 吉林大学学报(医学版), 2013, 39(3): 625-629.
[9]	周超熙,于滨,赵斌,马志强,赵文河,于跃明. 直肠癌环周切缘病理学检测判断中低位直肠癌患者预后的临床价值[J]. 吉林大学学报(医学版), 2013, 39(3): 601-604.
[10]	周广宇，韩雪梅，金玲. 神经精神狼疮患者影像学表现与自身抗体水平和预后的关系[J]. 吉林大学学报(医学版), 2013, 39(3): 609-614.
[11]	周建英，田勇韩青,贺庆,程凯亮,李幼琼. 影像学三维重建技术在寰椎立体模型建立及性别鉴定中的应用[J]. 吉林大学学报(医学版), 2013, 39(3): 605-608.
[12]	沈煜，沈惠良，方秀统. 老年股骨颈骨折患者关节置换术后死亡危险因素分析[J]. 吉林大学学报(医学版), 2013, 39(3): 574-577.
[13]	王宗谦，卢新星. 终末期肾病患者抑郁程度与生存质量各个维度之间的关系[J]. 吉林大学学报(医学版), 2013, 39(3): 615-619.
[14]	李树春，王槐. 影响美托洛尔治疗效果的药物基因组学研究进展[J]. 吉林大学学报(医学版), 2013, 39(2): 423-426.
[15]	胡源，贾卉，姜瑞，李京，刘涛涛. 不同验光方法对中年患者屈光状态的检测及其临床意义[J]. 吉林大学学报(医学版), 2013, 39(2): 363-366.