关键词: 支气管哮喘；布地奈德；特布他林；β2肾上腺素能受体；T细胞亚群

Abstract:

Objective  To investigate the influence of terbutaline in combination with inhalation of budesonide  on the β2-adrenergic receptor， T lymphocyte subgroup and eosinophile granulocyte (EOS) and the improvement effect on lung function in the acute attack asthmatic patients.Methods 56 patients with moderate and severe acute attack asthma were selected and randomly divided into control group and  treatment group（n＝28）.The patients in control group were treated with  common method such as doxofylline and the patients in treatment group were treated with an additional treatment by applying combination inhalation: budesonide + terbutaline,two times a day;the β2ADR,T lymphocyte  subgroup,EOS, and lung function were detected before and after  treatment.Results There was no change  in the level of  β2AR in peripheral blood of patients after treatment in  two groups(P>0.05);CD4%,CD4/CD8 and EOS counts　of the patients  were obviously reduced(P<0.05),PEF and FEV1/FVC were obviously increased(P<0.05) after treatment  in two groups,the effect was  obvious in  treatment group compared with control group(P<0.05).Conclusion The combination inhalation has the effect of improving asthmatic patient in acute attack period and achieving clinical control in the long term.

Key words: bronchial asthma;budesonide;terbutaline;β2-adrenergic receptor;T lymphocyte subgroup