Abstract:

Methods A total of 7 560 healthy physical examination population aged 20－79 years old in the Physical Examination Center of Antu County Hospital in Yanbian Korean Autonomous Prefecture were selected by cluster sampling method. They were divided into MS and its related metabolic abnormality group and MS and its related metabolic index normal group according to the diagnostic criteria of MS. Gender， age， height， body mass， systolic blood pressure， diastolic blood pressure， and fasting serum glucose（FBG）， triglycerides（TG），high-density lipoprotein cholesterol（HDL-c）， SUA and γ- GGT and other indicators the subjects in various groups were collected. Logistic regression analysis was used to detect the risks of different metabolic index disorders of the patients，and to analyze the interactions of different metabolic disorders of the patients. Results The risks of hyperuricemia （HUA） and elevated γ-GGT level of the subjects in MS and its related metabolic abnormality group were higher than those in MS and its related metabolic index normal group， and the risk of MS and its related metabolic abnormalities were increased gradually with the increasing of SUA and γ- GGT levels. The risks of increased HUA and γ-GGT levels of the subjects in MS and its related metabolic index abnormality group were 4.660 times（95%CI：3.571－6.085） and 5.260 times（95%CI：4.009－6.897） higher than those in MS and its related metabolic index normal group； with the increasing of degrees of the metabolic abnormalities， the risks of elevated HUA and γ-GGT levels of the subjects were increased.The risks of obesity， hypertension，dyslipidemia， hyperglycemia and MS of the subjects in increased SUA level and increased γ-GGT group were 1.930（95%CI：1.617－2.304）， 1.618（95%CI：1.352－1.935），4.011（95%CI：3.245－4.958），1.989（95%CI：1.654－2.393）， and 2.695（95%CI：2.248－3.230） times higher than those in normal SUA level and normal γ-GGT level groups，respectively. There was additive interaction between increased SUA and γ-GGT levels on dyslipidemia， and the synergy index（S） and attributable proportion due to interaction were 1.17 and 10.9%， respectively. Conclusion The SUA and γ-GGT levels are closely related to the risks of MS and its related metabolic abnormalities， and the increased SUA and γ-GGT levels are associated with the degree of metabolic abnormalities. HUA combined with increased γ-GGT level can significantly increase the risks of hypertension， dyslipidemia and MS， and increased SUA and γ-GGT levels have an additive interaction on the dyslipidemia. Objective To analyze the relationship between the serum uric acid （SUA） and γ-glutamyl transpeptidase（γ-GGT） levels and metabolic syndrome （MS） and discuss the interaction of SUA and γ-GGT in MS， and to provide the basis for the risk prediction and early intervention of MS.

Key words: Serum uric acid, γ-glutamyl transpeptidase, Metabolic disorder, Correlation, Healthy physical examination population