幽门螺杆菌与代谢综合征关联性及其对代谢综合征发生发展影响的研究进展

doi:10.13481/j.1671-587X.20240631

Abstract

Abstract:

Metabolic syndrome （MS） is a complex syndrome based on metabolic disorders in the human body， and is a risk factor for cardiovascular diseases and even certain tumors， with a complicated etiology and unclear pathogenesis. Helicobacter pylori （Hp） is one of the most common pathogenic bacteria， closely associated with the occurrence and development of various diseases. Currently， there are numerous studies both domestically and internationally on the relationship between Hp and MS and its components. Most studies suggest that there is an association between Hp and MS and Hp influences the occurrence and development of MS through multiple pathways. Eradicating Hp may become a new option for treating MS. Based on recent studies from both domestic and international sources， this paper discusses the association between Hp and MS， analyzes the effects of Hp on obesity， blood glucose， blood lipids， and blood pressure， and aims to provide new ideas for the prevention and treatment of MS.

Key words: Helicobacter pylori, Metabolic syndrome, Metabolic disorder, Obesity, Blood glucose

CLC Number:

R589

Yanbin ZHANG,Guangye GUO,Caihua ZHENG,Xinyan LIU. Research progress in association between Helicobacter pylori and metabolic syndrome and its effect on occurrence and development of metabolic syndrome[J].Journal of Jilin University(Medicine Edition), 2024, 50(6): 1757-1762.

References 49

1	LIU Y， SHUAI P， CHEN W J， et al. Association between Helicobacter pylori infection and metabolic syndrome and its components［J］. Front Endocrinol， 2023， 14： 1188487.
2	郝晶晶，孙菁，燕文敬. 幽门螺杆菌感染与代谢综合征的相关性［J］. 中华医院感染学杂志， 2023， 33（6）： 856-859.
3	KOUNTOURAS J， PAPAEFTHYMIOU A， POLYZOS S A， et al. Impact of active helicobacter pylori infection-related metabolic syndrome on systemic arterial hypertension［J］. Arq Bras Cardiol， 2022， 119（3）： 502-504.
4	韩怡，闫静静，方新鑫，等. 幽门螺杆菌现症感染与代谢综合征的相关性分析［J］. 实用临床医药杂志， 2021， 25（20）： 37-41.
5	IBRAHIM A S， ELDEEB M M， SALAMA O A， et al. Possible association of ghrelin/obestatin balance with cardiometabolic risk in obese subjects with Helicobacter pylori ［J］. Endocr Regul， 2018， 52（2）： 101-109.
6	ALEID A， BALKHI A A， HUMMEDI A， et al. The utility of esophagogastroduodenoscopy and Helicobacter pylori screening in the preoperative assessment of patients undergoing bariatric surgery： a cross-sectional， single-center study in Saudi Arabia［J］. Saudi J Gastroenterol， 2020， 26（1）： 32-38.
7	ZHANG J S， CHEN Y H， CHEN W L， et al. Persistent infection of Helicobacter pylori affects weight loss in obese population compared with persistent negative： a case-control study based on healthy Chinese［J］. Helicobacter， 2020， 25（4）： e12697.
8	SUKI M， LEIBOVICI WEISSMAN Y， BOLTIN D， et al. Helicobacter pylori infection is positively associated with an increased BMI， irrespective of socioeconomic status and other confounders： a cohort study［J］. Eur J Gastroenterol Hepatol， 2018， 30（2）： 143-148.
9	WAN Z C， SONG L L， HU L， et al. Helicobacter pylori infection is associated with diabetes among Chinese adults［J］. J Diabetes Investig， 2020， 11（1）： 199-205.
10	CHENG K P， YANG Y J， HUNG H C， et al. Helicobacter pylori eradication improves glycemic control in type 2 diabetes patients with asymptomatic active Helicobacter pylori infection［J］. J Diabetes Investig， 2019， 10（4）： 1092-1101.
11	KATO M， TODA A， YAMAMOTO-HONDA R， et al. Association between Helicobacter pylori infection， eradication and diabetes mellitus［J］. J Diabetes Investig， 2019， 10（5）： 1341-1346.
12	黄站梅，徐婉星，刘珍玲，等. 幽门螺杆菌定值水平与代谢综合征及非酒精性脂肪肝的相关性研究［J］. 江西医药， 2021， 56（11）： 1879-1884.
13	王永平，张丹，周莹，等. 胃内幽门螺杆菌定植水平与代谢综合征的关系［J］. 现代消化及介入诊疗， 2020， 25（5）： 576-580.
14	YANG Y F， LI Y， LIU J H， et al. Relation of Helicobacter pylori infection to peripheral arterial stiffness and 10-year cardiovascular risk in subjects with diabetes mellitus［J］. Diab Vasc Dis Res， 2020， 17（5）： 1479164120953626.
15	HUANG M Y， ZHU L J， JIN Y L， et al. Association between Helicobacter pylori infection and systemic arterial hypertension： a meta-analysis［J］. Arq Bras Cardiol， 2021， 117（4）： 626-636.
16	KIM Y I， KIM Y A， LEE J W， et al. Effect of Helicobacter pylori treatment on long-term mortality in patients with hypertension［J］. Gut Liver， 2020， 14（1）： 47-56.
17	申海彬，沈志明，廖建芳，等. 赣南地区幽门螺旋杆菌与2型糖尿病和代谢综合征相关性研究［J］. 临床医药实践， 2022， 31（2）： 99-102.
18	UPALA S， JARUVONGVANICH V， RIANGWIWAT T， et al. Association between Helicobacter pylori infection and metabolic syndrome： a systematic review and meta-analysis［J］. J Dig Dis， 2016， 17（7）： 433-440.
19	仲蕊，张苗，王梦兰，等. 幽门螺杆菌感染与代谢综合征参数变化的相关性研究［J］. 胃肠病学和肝病学杂志， 2020， 29（5）： 556-560.
20	LIOU J M， CHEN C C， CHANG C M， et al. Long-term changes of gut microbiota， antibiotic resistance， and metabolic parameters after Helicobacter pylori eradication： a multicentre， open-label， randomised trial［J］. Lancet Infect Dis， 2019， 19（10）： 1109-1120.
21	李刚，曹素艳，张野，等. 幽门螺杆菌感染与腹型肥胖的相关性研究［J］. 中华全科医师杂志， 2022， 21（4）： 361-366.
22	ZHOU M G， LIU J， QI Y， et al. The association between Helicobacter pylori seropositivity and risk of new-onset diabetes： a prospective cohort study［J］. Diabetologia， 2018， 61（2）： 300-307.
23	COUMES S， FROISSART B， WION N， et al. Prevalence and factors associated with Helicobacter pylori in patients undergoing bariatric surgery： the SOON cohort［J］. Obes Surg， 2018， 28（12）： 3958-3964.
24	OKUSHIN K， TAKAHASHI Y， YAMAMICHI N， et al. Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease： a large-scale cross-sectional study in Japan［J］. BMC Gastroenterol， 2015， 15： 25.
25	刘世雄，赵丽，周芸，等. 根除幽门螺旋杆菌对高龄2型糖尿病患者血糖的影响［J］. 中华老年医学杂志， 2020， 39（2）： 168-171.
26	包萨如拉，杜晓旭，戈宏焱. 幽门螺杆菌感染联合传统危险因素预测代谢相关脂肪性肝病发生风险的价值分析［J］. 临床肝胆病杂志， 2023， 39（6）： 1318-1324.
27	RESHETNYAK V I， BURMISTROV A I， MAEV I V. Helicobacter pylori： commensal， symbiont or pathogen？［J］. World J Gastroenterol， 2021， 27（7）： 545-560.
28	WANG L， CAO Z M， ZHANG L L， et al. Helicobacter pylori and autoimmune diseases： involving multiple systems［J］. Front Immunol， 2022， 13： 833424.
29	KONDHALKAR A， BAROKAR R， WARJUKAR P， et al. Study of TNF-α， IL-6 and insulin resistance in type 2 diabetes mellitus at vidharbha region［J］. J Pharm Res Int， 2021： 534-539.
30	肖佳佳，韦晓洁，李静，等. 健康体检人群中幽门螺杆菌感染与代谢综合征检测指标之间的关系［J］. 现代消化及介入诊疗， 2020， 25（6）： 783-785.
31	CHEN Y H， XU C L， XU H F， et al. Persistent Helicobacter pylori infection for more than 3years leads to elevated serum homocysteine concentration： a retrospective cohort study based on a healthy Chinese population［J］. J Gastroenterol Hepatol， 2021， 36（11）： 3077-3083.
32	黄览，王道敏，黄赞松，等. 幽门螺杆菌定植与致病机制的研究新进展［J］. 中国医学创新， 2022， 19（14）： 166-170.
33	胡奕，何晨，吕农华. 核因子κB信号通路在幽门螺杆菌致病中的作用［J］. 中华消化杂志， 2020， 40（11）： 790-792.
34	NINOMIYA R， KUBO， BABA T， et al. Inhibition of low-density lipoprotein uptake by Helicobacter pylori virulence factor CagA［J］. Biochem Biophys Res Commun， 2021， 556： 192-198.
35	YANG S， XIA Y P， LUO X Y， et al. Exosomal CagA derived from Helicobacter pylori-infected gastric epithelial cells induces macrophage foam cell formation and promotes atherosclerosis［J］. J Mol Cell Cardiol， 2019， 135： 40-51.
36	CHOI J M， LIM S H， HAN Y M， et al. Association between Helicobacter pylori infection and arterial stiffness： results from a large cross-sectional study［J］. PLoS One， 2019， 14（8）： e0221643.
37	ZHU P， XUE J， ZHANG Z J， et al. Helicobacter pylori VacA induces autophagic cell death in gastric epithelial cells via the endoplasmic reticulum stress pathway［J］. Cell Death Dis， 2017， 8（12）： 3207.
38	SUZUKI H， ATAKA K， ASAKAWA A， et al. Helicobacter pylori vacuolating cytotoxin A causes anorexia and anxiety via hypothalamic urocortin 1 in mice［J］. Sci Rep， 2019， 9（1）： 6011.
39	窦广仙，贾惠娟，王萍，等. 高脂饮食对幽门螺杆菌感染胃黏膜损伤小鼠胃肠激素的影响［J］. 中华医院感染学杂志， 2021， 31（22）： 3391-3396.
40	汪湃，冯世兵，晋颖. CYP2C19基因多态性与幽门螺杆菌感染后胃癌易感性研究［J］. 中华医院感染学杂志， 2020， 30（2）： 170-173.
41	朱秀云，徐晓辉，段磊，等. 体检人群幽门螺杆菌感染现状及与糖脂代谢、胃肠激素、 miR-26a水平的关联性分析［J］. 重庆医学， 2022， 51（3）： 418-422.
42	RAJILIC-STOJANOVIC M， FIGUEIREDO C， SMET A， et al. Systematic review： gastric microbiota in health and disease［J］. Aliment Pharmacol Ther， 2020， 51（6）： 582-602.
43	王子靖，李在玲. 有幽门螺杆菌感染家族史儿童胃部菌群的特点［J］. 北京大学学报（医学版）， 2021， 53（6）： 1115-1121.
44	HEIMESAAT M M， FISCHER A， PLICKERT R， et al. Helicobacter pylori induced gastric immunopathology is associated with distinct microbiota changes in the large intestines of long-term infected Mongolian gerbils［J］. PLoS One， 2014， 9（6）： e100362.
45	姚芸霞，王中华. 拉萨市健康人群与Hp感染者肠道菌群多样性特征［J］. 西藏科技， 2022（6）： 61-64.
46	钟超，杨培，李根秀. 高脂血症患者肠道菌群宏观分布与血清血脂水平的相关性研究［J］. 现代诊断与治疗， 2022， 33（9）： 1341-1344.
47	AIMASSO U， D’ONOFRIO V， D’EUSEBIO C， et al. Helicobacter pylori and nutrition： a bidirectional communication［J］. Minerva Gastroenterol Dietol， 2019， 65（2）： 116-129.
48	ZHOU X Y， LIU W， GU M， et al. Helicobacter pylori infection causes hepatic insulin resistance by the c-Jun/miR-203/SOCS3 signaling pathway［J］. J Gastroenterol， 2015， 50（10）： 1027-1040.
49	唐奥娟. 脂联素在Hp感染合并NAFLD中的表达及相关性分析［D］. 长沙：湖南师范大学， 2020.

[1]	Linghui LIN,Na LI,Xiaoyan YIN,Xiaoling WANG,Yaping HU,Wei LIU,Rui FEI,Xinli TIAN. Bioinformatics anlysis based on three-dimensional structure of Helicobacter pylori hp0169 gene [J]. Journal of Jilin University(Medicine Edition), 2024, 50(3): 739-748.
[2]	Kaihua YU,Kun WEI,Jie ZHANG,Xuemei YI,Gang WANG,Lei PANG. Heart failure patient with acute left lower limb arterial embolism complicated with myonephropathic metabolic syndrome: A case report and literature review [J]. Journal of Jilin University(Medicine Edition), 2024, 50(2): 529-535.
[3]	Yajie GE,Wen XU,Shimin GUAN,Lina WANG. Research progress in etiology and pathogenesis of polycystic ovary syndrome [J]. Journal of Jilin University(Medicine Edition), 2024, 50(1): 288-294.
[4]	Yanchun QIN,Yanqiang HUANG,Gang LU,Ganrong HUANG,Huaying TANG,Yuanyuan DAI. Distribution characteristics of micrflora in various regions of intestinal tract of mice with chronic gastritis infected with Helicobacter Pylori andits mechannism [J]. Journal of Jilin University(Medicine Edition), 2023, 49(2): 289-297.
[5]	Yihua LI,Tao WEN,Yongri QIAN,Chunshan ZHAO. Correlation analysis on relationships between levels of serum uric acid and γ-glutamyl transpeptidase and metabolic syndrome in healthy physical examination population [J]. Journal of Jilin University(Medicine Edition), 2022, 48(6): 1605-1613.
[6]	Zhao JIN,Rushuai WANG,Zhaoyang WANG,zhanbiao HE,Fuming TIAN,Ruijun WANG. Effect of Parnassia palustris Linn extracts on Helicobacter pylori colonization in gastric mucosa and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2022, 48(5): 1131-1138.
[7]	Shuang HUANG,Chen CHEN,Bo HUANG. Effects of limonin on lipid metabolism and intestinal flora in nutritionally obese rats [J]. Journal of Jilin University(Medicine Edition), 2022, 48(4): 858-865.
[8]	Shunjia SONG,Xinying WANG,Feifei JIANG,Huijian JIA,Yuan ZHAO,Zhiping YANG,Liyuan SUN,Yundong ZHAO. Resistance rates of Helicobacter pylori to clarithromycin, metronidazole, and levofloxacin and mutation characteristics of their related drug resistance genes [J]. Journal of Jilin University(Medicine Edition), 2022, 48(3): 630-637.
[9]	Mimi REN,Menghan GAO,Jing WANG,Jiamei LAI,Jinyu YU,Hang YUAN. Protective effect of 12/15-lipoxygenase gene knockout on kidney tissue of obesity-related glomerulopathy model mice and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2021, 47(6): 1337-1346.
[10]	Yong HE,Li HONG,Guotao HUANG,Zhihan ZHAO. Effect of palmitic acid on induction of lipid deposition in skeletal muscle cells [J]. Journal of Jilin University(Medicine Edition), 2021, 47(6): 1380-1385.
[11]	Yan ZHAO,Pengcheng YU,Yu WANG,Yingping WANG,Pingya LI,Jinping LIU. Effect of apoptosis of 3T3-L1 adipocytes induced by panaxadiol and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2021, 47(5): 1154-1161.
[12]	ZHANG Yezhuo, YANG Yuefeng, YANG Yetong, ZHANG Ying, LIU Yajuan. Effects of poria cocos compound extract on blood glucose and lipid levels in rats with type 2 diabetes mellitus [J]. Journal of Jilin University(Medicine Edition), 2020, 46(05): 937-941.
[13]	DU Xingxu, QIAO Zijing, YANG Shuo, XU Zhiying, YANG Bo, LI He, CHEN Jianguang, WANG Chunmei. Effect of Schisandra chinensis polysaccharide on serum inflammatory factors in T2DM rats and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2020, 46(01): 50-55.
[14]	LIU Fenxia, CHEN Li, SUN Ning, WU Yawei. Effect of Helicobacter pylori virulence factor CagA-mediated activation of ERK signaling pathway on proliferation and apoptosis of gastric cancer cells [J]. Journal of Jilin University(Medicine Edition), 2019, 45(05): 1063-1068.
[15]	ZHAO Jun, LIANG Jinyu. Improvement effects of aerobic exercise combined with resistance training on body composition, cardiovascular function and serum C-reactive protein level in male obese college students [J]. Journal of Jilin University(Medicine Edition), 2019, 45(05): 1134-1140.

Research progress in association between Helicobacter pylori and metabolic syndrome and its effect on occurrence and development of metabolic syndrome

RichHTML

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References 49

Related Articles 15

Metrics

Comments

Recommended 0