ACE基因单核苷酸多态性与冠心病易感性的关联性分析

doi:10.13481/j.1671-587x.20150430

Abstract

Abstract:

Objective To explore the association between single nucleotide polymorphisms(SNPs) of angiotensin converting enzyme (ACE) and susceptibility of coronary heart disease in Han population from North China,and to clarify whether ACE gene is the susceptible gene of coronary heart disease. Methods Using case-control study,246 patients with coronary heart disease confirmed with coronary angiography were used as case group,and 251 health persons were selected as control group.PCR-RFLP was applied to detect the SNPs of rs4267385 and rs4316 in ACE gene. Statistical software SPSS17.0 was used to analyze the assiation between ACE gene polymorphisms and coronary heart disease. Results The genotype distributions of the two SNPs(rs4267385,rs4316) didn't deviate from Hardy-Weinberg equilibrium in both case and control groups(P> 0.05); the allelic and genotypic frequency distributions of rs4267385 in ACE gene showed significant differences betwwen case and control groups(P<0.05),and the allelic and genotypic frequency distributions of rs4316 in ACE gene showed no significant differences betwwen case and control groups(P> 0.05). Conclusion ACE gene is likely to be the susceptible gene of coronary heart disease in Han population from North China.

Key words: angiotensin converting enzyme gene, coronary heart disease, single nucleotide polymorphism

CLC Number:

R541.4

WU Juan, JIA Yiyang, LIU Te, ZHOU Liting, SUN Di, XU Jin, LI Chunyan, WANG Shuyue, YU Lei, YE Lin. Analysis on association between single nucleotide polymorphisms of ACE gene and susceptibility of coronary heart disease[J].Journal of Jilin University Medicine Edition, 2015, 41(04): 825-829.

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Analysis on association between single nucleotide polymorphisms of ACE gene and susceptibility of coronary heart disease

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