塑化剂DEHP暴露人群血清甲状腺激素水平变化的Meta分析

doi:10.13481/j.1671-587x.20170114

Abstract

Abstract:

Objective: To systematically evaluate the changes of serum thyroid hormone levels in di-2-ethylhexyl phthalate (DEHP) exposure population,and to provide a scientific evidence for the study on pathogenesis of thyroid disease.Methods: The studies about the association between DEHP exposure and thyroid hormone levels published with Chinese and English were electronically searched in PubMed,EMbase,CNKI database,WanFang database and VIP Chinese Journal Database up to July 1,2016. According to the inclusion and exclusion criteria,the data was extracted and screened by two researchers.The results of Meta-analysis were performed using RevMan 5.2 software.Results: Seven studies were finally screened,including one high-quality and six medium-quality studies.All studies were published with English,involving 5 692 samples.The results of Meta-analysis showed that the levels of serum TSH,FT4 and T4 were reduced respectively by 10% (OR=0.10,95%CI:0.02-0.44,P=0.002),6% (OR=0.06,95%CI,0.00-0.81, P=0.03),and 7% (OR=0.07,95%CI:0.01-0.39,P=0.002),with the increasing of urine mono-2-ethylhexyl phthalate (MEHP) level with 1 μg·L^-1, whereas the relation between DEHP and T3 had no statistical significance (P=0.11).Conclusion: Human DEHP exposure can reduce the levels of thyroid hormones in different degrees.

Key words: Meta-analysis, thyroid hormones, di-2-ethylhexyl phthalate, human exposure

CLC Number:

SUN Di, WANG Qi, CHEN Haiji, XU Feng, ZHANG Yuezhu, ZHANG Tianrong, LIU Hongbo, YE Lin. Changes of serum thyroid hormone levels in DEHP exposure population: A Meta-analysis[J].Journal of Jilin University Medicine Edition, 2017, 43(01): 66-72.

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Changes of serum thyroid hormone levels in DEHP exposure population: A Meta-analysis

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