Abstract:

Objective To investigate the expression of osteopontin(OPN) in ova
rian serous cystadenocarcinoma tissues and explore the relationship with clinicopathological characteristics.
Methods  The expressions of OPN in 70 cases of ovarian serous cystadenocarcinoma tissues,22 cases of ovarian serous cystadenoma tissues,and 15 cases of normal ovarian tissues were detected by immunohistochemistry method.Results ① The positive expression rate of OPN in ovarian serous cystadenocarcinoma tissues was 82.9%,much higher than those in ovarian serous cystadenoma tissues(22.7%) and nomal ovarian tissues(13.3%)(P<0.05).② The positive expression rates of OPN in stage Ⅰ，stage Ⅱ，stage Ⅲ，stage Ⅳovarian serous cystadenocarcinoma tumor tissues were 60.0％, 76.2％, 96.2％,and 100.0％.The po
sitive rate of OPN expression in stageⅢ and Ⅳ tumor tissues(97.1%) was   dramatically higher than that in stage Ⅰand stage Ⅱ (69.4%)(P<0.05).The positive expression rates of OPN in G1，G2，and G3 ovarian serous cystadenocarcinoma tumor tissues were 74.1％,80.0％ and 95.7％,it was dramatically higher in G3 tumor tissues than that in G1 tumor tissues(P<0.05).There was correlation between the positive rate of OPN
and pathological grading and clinical stages,the later clinical stage and the worse differentiation of ovarian serous cystadenocarcinoma,the stronger positive expression rate of OPN.③The positive expression rate of OPN in ovarian serous cystadenocarcinoma tumor  tissues with ascites（95.2%）was higher than that in tumor tissues without ascites(64.3%)(P<0.05).Conclusion Overexpression of OPN may promote the development,invasion and metastasis of ovarian serous cystadenocarcinom.The detection of OPN  can be used as a prognostic marker in judgement of malignant degree and prognosis  in ovarian cancer patients.

Key words: osteopontin, ovarian serous cystadenocarcinoma, immunohistochemistry