骨桥蛋白和趋化因子受体4在卵巢肿瘤组织中的表达及其意义

doi:10.13481/j.1671-587x.20150617

Abstract

Abstract:

Objective To analyze the expressions of osteopontin(OPN) and chemokine(CXC-subfamily)receptor 4(CXCR4) in different ovarian tissues,and to explore the role of OPN and CXCR4 in occurrence,development and metastasis of human ovarian cancer. Methods The expressions of OPN and CXCR4 in normal ovarian tissue(n=20),benign ovarian epithelial tumor(n=20) and epithelial ovarian cancers tissues(n=40) were detected by immunohistochemical SP method, and the expression rates of OPN and CXCR4 in epithelial ovarian cancer tissue with different clinical characteristics were analyzed. Results The positive expressions rate of OPN in epithelial ovarian cancer tissue was significantly higher than those in normal ovarian tissue and benign ovarian tumor tissue,and there were significant differences in the positive expression rates of OPN between different pathological stages (G₁,G₂,G₃) of epithelial ovarian cancer (P<0.05).Meanwhile,the positive expression rate of OPN in Ⅲ-Ⅳ epithelial ovarian cancer tissue was significantly higher than that in Ⅰ-Ⅱ epithelial ovarian cancer tissue (P<0.05).However,there were no significant differences of the positive expression rates of OPN among different histological types of epithelial ovarian cancer tissue (P>0.05).There was no positive expression of CXCR4 protein in normal ovarian tissue and benign ovarian tumor tissues,but there was positive expression in epithelial ovarian cancer tissue.Besides,the expressions of CXCR4 protein were not significantly different among different pathological grades,different clinical stages and different histological types (P>0.05). Conclusion The OPN and CXCR4 expression levels are correlated with the degrees of malignancy in epithelial ovarian tumor,therefore the CXCR4 and OPN expression pathways may be the new targets for ovarian cancer therapy.

Key words: osteopontin, chemokine(CXC-subfamily)receptor 4, ovarian neoplasms, immunohistochemistry

CLC Number:

R737.71

WANG Kun, ZHANG Aichen, SHENG Minjia, PAN Ying, TONG Lingling, SUN Xiaochun. Expressions of OPN and CXCR4 in human epithelial ovarian cancer tissueand their clinical significances[J].Journal of Jilin University Medicine Edition, 2015, 41(06): 1186-1189.

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Expressions of OPN and CXCR4 in human epithelial ovarian cancer tissueand their clinical significances

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