Journal of Jilin University(Medicine Edition) ›› 2021, Vol. 47 ›› Issue (5): 1264-1272.doi: 10.13481/j.1671-587X.20210526
• Research in clinical medicine • Previous Articles Next Articles
Guangcai WAN,Hongshuai SUN,Hua ZHU,Xiuyan YU()
Received:
2021-01-09
Online:
2021-09-28
Published:
2021-10-26
Contact:
Xiuyan YU
E-mail:yuxiuyan1968@sohu.com
CLC Number:
Guangcai WAN,Hongshuai SUN,Hua ZHU,Xiuyan YU. Effect of NLR and PLR on prognosis of small-cell lung cancer patients received platinum-based first-line chemotherapy: A Meta-analysis[J].Journal of Jilin University(Medicine Edition), 2021, 47(5): 1264-1272.
Tab. 1
Basic characteristics of SCLC patients included in this study"
First author | Publication year | Region | Nation | Sample size | Age(year) | |
---|---|---|---|---|---|---|
SAKIN,et al [ | 2019 | Asia | Turkey | 113 | Median 61(35-81) | |
PAN,et al [ | 2019 | Asia | China | 73 | Mean 61.64(39-83) | |
SUZUKI,et al [ | 2018 | North America | America | 252 | Median 63(56-69) | |
SUZUKI,et al [ | 2018 | North America | America | 122 | Median 65 (60-72) | |
WEN,et al [ | 2017 | Asia | China | 452 | Median 56(27-82) | |
KASMANN,et al [ | 2017 | Europe | Germany | 65 | NG | |
CAO,et al [ | 2016 | Asia | China | 707 | Mean 56.24(23-75) | |
SHAO,et al [ | 2015 | Asia | China | 112 | Median 62(45-82) | |
XIE,et al [ | 2015 | North America | America | 938 | Median 68(27-91) | |
KANG,et al [ | 2014 | Asia | Korea | 187 | Median 68(43-84) | |
WANG,et al [ | 2014 | Asia | China | 613 | Mean 59.31 | |
First author | Follow-up /months | Analysis mode | NLR cutoff | PLR cutoff | Outcome endpoint | NOS score |
SAKIN,et al [ | Median 6(1-33) | MV+UV | 3.00 | 150.0 | OS | 7 |
PAN,et al [ | NG | UV | 3.80 | NG | OSKM, PFSKM | 6 |
SUZUKI,et al [ | NG | MV+UV | 4.00 | 194.7 | OS | 8 |
SUZUKI,et al [ | NG | MV+UV | 2.90 | 140.1 | OS | 8 |
WEN,et al [ | Median 35.1 | MV | 4.00 | NG | OS,PFS | 9 |
KASMANN,et al [ | NG | MV | 4.00 | 180.0 | OS | 7 |
CAO,et al [ | NG | MV | 3.18 | 176.5 | OS | 9 |
SHAO,et al [ | Median 68.5 | MV | 4.15 | 150.0 | OS,PFS | 8 |
XIE,et al [ | Median 10.8 | MV | 5.00 | 210.0 | OS | 7 |
KANG,et al [ | Median 40.28(2.60-89.20) | MV | 4.00 | 160.0 | OS,PFS | 8 |
WANG,et al [ | NG | MV | 3.00 | 150.0 | OS | 7 |
1 | PAZ-ARES L, DVORKIN M, CHEN Y, et al. Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN):a randomised, controlled, open-label, phase 3 trial[J].Lancet,2019, 394(10212):1929-1939. |
2 | KASMANN L, ABDO R, EZE C, et al. External validation of a survival score for limited-stage small cell lung cancer patients treated with chemoradiotherapy[J]. Lung, 2020, 198(1): 201-206. |
3 | WU Q, XIONG Y T, ZHANG S J, et al. A meta-analysis of the efficacy and toxicity of twice-daily vs. once-daily concurrent chemoradiotherapy for limited-stage small cell Lung Cancer Based on randomized controlled trials[J]. Front Oncol, 2019, 9: 1460. |
4 | HORN L, MANSFIELD A S, SZCZESNA A, et al. First-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer[J]. N Engl J Med, 2018, 379(23): 2220-2229. |
5 | SHEN X B, WANG Y, SHAN B J, et al. Prognostic significance of platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) during etoposide-based first-line treatment in small cell lung cancer patients[J]. 2019, 11: 8965-8975. |
6 | SACDALAN D B, LUCERO J A, SACDALAN D L. Prognostic utility of baseline neutrophil-to-lymphocyte ratio in patients receiving immune checkpoint inhibitors: a review and meta-analysis[J]. Onco Targets Ther, 2018, 11: 955-965. |
7 | BAGLEY S J, KOTHARI S, AGGARWAL C, et al. Pretreatment neutrophil-to-lymphocyte ratio as a marker of outcomes in nivolumab-treated patients with advanced non-small-cell lung cancer [J].Lung Cancer,2017,106: 1-7. |
8 | BOWEN R C, LITTLE N A B, HARMER J R, et al. Neutrophil-to-lymphocyte ratio as prognostic indicator in gastrointestinal cancers: a systematic review and meta-analysis[J]. Oncotarget, 2017, 8(19): 32171-32189. |
9 | KANG M H, GO S I, SONG H N, et al. The prognostic impact of the neutrophil-to-lymphocyte ratio in patients with small-cell lung cancer[J]. Br J Cancer, 2014, 111(3): 452-460. |
10 | SAKIN A, SAHIN S, YASAR N, et al. The relation between hemogram parameters and survival in extensive-stage small cell lung cancer[J]. Oncol Res Treat, 2019, 42(10): 506-515. |
11 | PAN Z C, ZHANG L, LIU C, et al. Cisplatin or carboplatin? Neutrophil to lymphocyte ratio may serve as a useful factor in small cell lung cancer therapy selection[J]. Oncol Lett, 2019, 18(2): 1513-1520. |
12 | XIE D, MARKS R, ZHANG M, et al. Nomograms predict overall survival for patients with small-cell lung cancer incorporating pretreatment peripheral blood markers[J]. J Thorac Oncol, 2015, 10(8): 1213-1220. |
13 | MOHER D, LIBERATI A, TETZLAFF J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement[J]. J Clin Epidemiol, 2009, 62(10): 1006-1012. |
14 | CAO S B, JIN S, SHEN J, et al. Selected patients can benefit more from the management of etoposide and platinum-based chemotherapy and thoracic irradiation-a retrospective analysis of 707 small cell lung cancer patients[J]. Oncotarget, 2017, 8(5): 8657-8669. |
15 | KASMANN L, BOLM L, SCHILD S E, et al. Neutrophil-to-lymphocyte ratio predicts outcome in limited disease small-cell lung cancer [J]. Lung, 2017, 195(2): 217-224. |
16 | PENG H, LUO X. Prognostic significance of elevated pretreatment systemic inflammatory markers for patients with prostate cancer: a meta-analysis[J]. Cancer Cell Int, 2019, 19: 70. |
17 | GUO W, LU X, LIU Q, et al. Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for breast cancer patients: an updated meta-analysis of 17079 individuals[J]. Cancer Med, 2019, 8(9): 4135-4148. |
18 | YANG S S, ZHAO K, DING X, et al. Prognostic significance of hematological markers for patients with nasopharyngeal carcinoma: a meta-analysis[J].J Cancer, 2019, 10(11): 2568-2577. |
19 | WEN Q, MENG X, XIE P, et al. Evaluation of factors associated with platinum-sensitivity status and survival in limited-stage small cell lung cancer patients treated with chemoradiotherapy[J]. Oncotarget,2017,8(46): 81405-81418. |
20 | SUZUKI R, LIN S H, WEI X, et al. Prognostic significance of pretreatment total lymphocyte count and neutrophil-to-lymphocyte ratio in extensive-stage small-cell lung cancer[J]. Radiother Oncol, 2018, 126(3): 499-505. |
21 | SUZUKI R, WEI X, ALLEN P K, et al. Prognostic significance of total lymphocyte count, Neutrophil-to-lymphocyte ratio, and Platelet-to-lymphocyte ratio in Limited-stage Small-cell lung cancer[J]. Clin Lung Cancer, 2019, 20(2): 117-123. |
22 | SHAO N, CAI Q. High pretreatment neutrophil-lymphocyte ratio predicts recurrence and poor prognosis for combined small cell lung cancer[J]. Clin Transl Oncol, 2015, 17(10): 772-778. |
23 | WANG X, JIANG R, LI K. Prognostic significance of pretreatment laboratory parameters in combined small-cell lung cancer[J].Cell Biochem Biophys,2014,69(3): 633-640. |
24 | HARAM A, BOLAND M R, KELLY M E, et al. The prognostic value of neutrophil-to-lymphocyte ratio in colorectal cancer: a systematic review[J]. J Surg Oncol, 2017, 115(4): 470-479. |
25 | LUCCA I, JICHLINSKI P, SHARIAT S F, et al. The neutrophil-to-lymphocyte ratio as a prognostic factor for patients with urothelial carcinoma of the bladder following radical cystectomy: validation and meta-analysis[J]. Eur Urol Focus, 2016, 2(1): 79-85. |
26 | YANG T, ZHU J, ZHAO L, et al. Lymphocyte to monocyte ratio and neutrophil to lymphocyte ratio are superior inflammation-based predictors of recurrence in patients with hepatocellular carcinoma after hepatic resection[J]. J Surg Oncol, 2017, 115(6): 718-728. |
27 | DIEM S, SCHMID S, KRAPF M, et al. Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte ratio (PLR) as prognostic markers in patients with non-small cell lung cancer (NSCLC) treated with nivolumab[J]. Lung Cancer, 2017, 111: 176-181. |
28 | FERRUCCI P F, ASCIERTO P A, PIGOZZO J,et al. Baseline neutrophils and derived neutrophil-to-lymphocyte ratio: prognostic relevance in metastatic melanoma patients receiving ipilimumab[J]. Ann Oncol, 2016, 27(4): 732-738. |
29 | ZHANG Q, QU Y L, LIU H Y, et al. Initial platelet-to-lymphocyte count as prognostic factor in limited-stage small cell lung cancer[J]. Biomark Med, 2019, 13(4): 249-258. |
30 | ROTONDO R, BERTOLOTTO M, BARISIONE G, et al. Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation[J]. J Leukoc Biol, 2011, 89(5): 721-727. |
31 | NIESWANDT B, HAFNER M, ECHTENACHER B, et al. Lysis of tumor cells by natural killer cells in mice is impeded by platelets[J].Cancer Res,1999,59(6):1295-1300. |
32 | YANG H B, XING M, MA L N, et al. Prognostic significance of neutrophil-lymphocyteratio/platelet-lymphocyteratioin lung cancers: a meta-analysis[J]. Oncotarget, 2016, 7(47):76769-76778. |
33 | 万广财, 孙洪帅, 朱 华, 等. 中性粒细胞/淋巴细胞比值与接受EGFR-TKIs治疗的非小细胞肺癌患者预后关系的Meta分析[J].吉林大学学报(医学版),2020,46(6):1267-1273. |
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