Abstract:

Objective To analyze the effectiveness and safety of escitalopram and citalopram in the treatment of  depression with Meta-analysis and to provide
reference for the application in clinic of escitalopram and citalopram.Methods Computer　search was performed using
 the Cochrane Central Register of Controlled Trial(Issue 3,2012)，Embase(1966 to 2012.9),PubMed(1948 to 2012.9),Ovid-medline(1966 to 2012.9),VIP（1989 to 2
012.9），CNKI(1979 to 2012.9),and WanFang(1981 to 2012.9),and the randomized controlled
trial (RCT) were collected,then the retrieved studies according to  inclusion and exclusion criteria were screened,and the qualities of included studies were evaluated and RevMan 5.2.1 software was used for Meta-analysis. Results  A total of 195 articles were found and 12 of which were finally included.There
 was no significant difference of effectiveness rates between escitalopram and citalopram in the treatment of depression［(χ2=5.82，df=11，
P=0.88，Z=0.93(P＝0.35）；95%CI （0.87，1.50）］.The incidence of adverse reaction of escitalopram was similar as that of citalopram［χ2=11.18，df=11，P=0.43，Z=0.48(P=0.63）；95%CI （0.75,1.19）］.Conclusion Escitalopram has the similar effectiveness and the incidence of adver
se reaction with citalopram in the treatment of depression.

Key words: escitalopram , citalopram, depression, Meta-analysis