The Mujicun copper (molybdenum) polymetallic orefield in the Taihang Mountains, is located in the secondary faulted basin developed in the upper block of detachment zone on the west side of the neck of the dumbbell shaped Laiyuan igneous complex, the northeastern pitching end of the Fuping mantle branch structure. It is composed of porphyry copper (molybdenum) deposit, skarn iron-copper deposit and hydrothermal vein lead-zinc-silver deposit in periphery, and become the most perspective large-scale copper (molybdenum) polymetallic orefield in Hebei Province at present. Considering the study of ore-forming material sources is crucial for further understanding the metallogenesis of the deposit and the direction of ore-prospecting, authors tested and analyzed sulfur, lead, carbon, hydrogen, oxygen, silicon, and rhenium isotopic compositions in such minerals from the ore as chalcopyrite, galena, pyrite, molybdenite, magnetite, quartz and gypsum. The data showed that the major value of δ34S changes from -3.5‰ to 3.2‰, with the average of 0.3‰;206Pb/204Pb from 15.566 0 to 17.072 0, with the average of 16.547 0;207Pb/204Pb from 15.031 0 to 15.523 0, with the average of 15.258 0;208Pb/204Pb from 36.292 0 to 37.375 0, with the average of 36.721 0;δ13C from -2.94‰ to -2.18‰, with the average of -2.62‰;δ30Si from -0.3‰ to 0.2‰, with the average of 0.0‰;w(Re) from 23.65 μg/g to 266.50 μg/g, with the average of 142.33 μg/g;δ18OH2O from -10.64‰ to 7.70‰, with the average of -1.47%, δD from -148.4‰ to -89.0‰, with the average of -113.7‰ which is less than that of the standard magmatic water. These isotopic data mentioned above show that the ore-forming materials were mainly derived from the deep source and the ore-forming solutions are mainly composed of magmatic water and partly of atmospheric water.