Aiming at the conflict between the modeling style and ergonomic design of sport vehicles, the general layout design of a domestic B-class SUV is taken as the main content. Firstly, the development process of automobile general layout scheme is introduced based on ergonomics to set the initial layout scheme. Secondly, the modelling and simulation software of ergonomics, RAMSIS, is used to check the proposed initial layout scheme. To solve the layout problems, the contradiction between the vehicle modeling style and the occupant arrangement in the vehicle is reconciled by adjusting several parameters and implementing partial improvement under the condition that the vehicle size definition remains unchanged. Finally, the subjective evaluation test is carried out on the automobile man-machine test platform.