Simulation analysis and experimental research were conducted to investigate the problem of operating consistency deviation of each cylinder in a high specific power V8 engine. Through the simulation analysis, the causes of the differences in the operation of each cylinder were clarified, the cam profile was optimized, and the effects of the profile optimization proposal for engine test on the operation consistency, power and economy performance of the V8 engine were analyzed. The test results show that the optimized intake cam profile can significantly improve the load deviation among cylinders under high speed and high load conditions, with a maximum improvement of 3.1% in the load consistency of each cylinder, while the engine full load, economy and emissions performance are the same as the base profile. The engine performance under partial load conditions are comparable to the basic profile, which confirms the effect of profile optimization.