In order to coordinate the longitudinal and lateral driving assistance systems and vehicle stability control objectives of intelligent driving vehicle, this paper proposes a vehicle integrated control strategy by integrating different driving assistance systems and vehicle stability control in a hierarchical model predictive control architecture to achieve the optimal distribution, taking the four-wheel independent drive electric vehicle as the plant. The upper layer calculates the generalized control force to meet the vehicle motion targets according to the decision results of the driving assistance strategies. The middle layer module includes two parts: the vehicle control targets prediction model and the numerical algorithm. And the desired vehicle tire forces can be obtained through the middle layer. The lower module decides the tire slip rate and slip angle according to the expected tire forces, and the tire forces are achieved by controlling the vehicle driving motor and the braking system, and the heading angle is regulated through the front wheel steering control system. Simulation and hardware-in-the-loop (HIL) verification results show that the proposed integrated control algorithm has good computation efficiency and the longitudinal and lateral control requirements of the vehicle can be ensured at the same time. Results show that the maximum errors of path tracking and velocity control are 0.011 7 m and 0.59 km/h, respectively.