关键词: 基因, p53, 受体, c-erbB-2, 基因, c-erbB-2, p21, nm23

Abstract: Objective To study the relationships between prognosis and expressions of p53,c-erbB-2, p21 and nm23 genes in gastric cancer tissue specimens and evaluate their values in diagnosis and treatment of gastric cancer. Methods The expressions of p53, c-erbB-2, p21 and nm23 were detected by immunohistochemical method in 123 surgically resected specimens. Results The positive expression rates of p53,c-erbB-2,p21 and nm23 in well-differentiation gastric cancer group were 38.0%(27/71)， 59.2%(42/71)， 39.4%(28/711) and 71.8%(51/71)， respectively；the positive rates in poor-differentiation group were 46.2%(24/52),36.5%(19/52), 69.2%(24/52) and 34.6%(18/52)，respectively.Expressions of p53，c-erbB-2，p21 and nm23 were not observed in non-tumor endoscopic biopsy specimens. The expressions of p53，c-erbB-2 ，p21 were positively correlated with grade of tumor differentiation ，the depth of tumor invasion and clinical different stages (r=0.53, r=0.67, r=0.48, P<0.05), and the expression of nm23 was negatively correlated with grade of tumor differentiation，the depth of tumor invasion and clinical different stages　(r=-0.36, P<0.05). Conclusion Determination of p53, c-erbB-2, p21 and nm23 might be useful in diagnosis and treatment of gastric cancer, differentiating benign and malignant tumor, clinical stages and better than single gene in predicting prognosis of gastric cancer. Key words：stomch neoplasms；gene p53； recepto r， c-erbB-2；gene， c-erbB-2，p21， nm23； prognosis

Key words: gene p53, receptor, c-erbB-2, gene, c-erbB-2, p21, nm23,