J4 ›› 2009, Vol. 35 ›› Issue (6): 1103-1106.

• 基础研究 • 上一篇    下一篇

宁夏回族原发性高血压人群HLA-DQB1基因多态性分析

 徐金瑞, 杨易, 张东涛, 高力扬, 王玉炯   

  1. 宁夏大学 西部特色生物资源保护与利用教育部重点实验室,宁夏 银川 750021
  • 收稿日期:2009-04-30 出版日期:2009-11-28 发布日期:2009-11-28
  • 基金资助:

    教育部科学技术研究重点项目资助课题(205172);宁夏大学自然科学基金资助课题(ZR0603)

Analysis on polymorphisms of HLA-DQB1 gene in Ningxia Hui |polulation with |essential hypertension

 XU Jin-Rui, YANG Yi, ZHANG Dong-Tao, GAO Li-Yang, WANG Yu-Jiong   

  1. Key Laboratory |for Protection and Utilization of Special Biological Resources in Western China, Ministry of Education, Ningxia University, Yinchuan 750021,China
  • Received:2009-04-30 Online:2009-11-28 Published:2009-11-28
  • About author:徐金瑞(1975-)|男|宁夏回族自治区永宁县人|讲师|遗传学硕士|主要从事医学遗传学研究。

摘要:

目的:分析HLA-DQB1基因多态性在宁夏回族人群原发性高血压(EH)患者中的分布,阐明宁夏回族人群原发性高血压的易感性。方法:采用序列特异性引物聚合酶链式反应(SSP-PCR)的方法对宁夏回族66例健康个体(对照组)及84例EH患者(病例组)的HLA-DQB1位点进行基因分型,应用遗传学统计方法分析宁夏回族原发性高血压人群DQB1基因多态性。结果:病例组等位基因DQB1*0301、*0401、*0601、*0604/5/6/7、*0302频率显著高于对照组(P<0.01或P<0.05);病例组等位基因DQB1*0501、*0602、*0603/8、*0606、*0402、*0604/5/6/8频率显著低于对照组(P<0.01或P<0.05)。结论:DQB1*0301、*0401、*0601、*0604/5/6/7、*0302与宁夏回族人群原发性高血压的易感性有关,而DQB1*0501、*0602、*0603/8、*0606、*0402、*0604/5/6/8有可能是宁夏回族人群原发性高血压的保护因子。

关键词: HLA抗原;易感性;高血压

Abstract:

Objective
To investigate the susceptibility to essential hypertension(EH) in Ningxia Hui population based on the distribution of   the polymorphisms of HLA-DQB1 in  EH population . Methods   PCR-SSP method was conducted to examine the genotypes of HLA-DQB1 in 66 healthy individuals and 84 EH patients,and the genotypic and allelic frequencies were statistically computed. Results The distribution of alleles was significantly different between two groups.The frequencies of *0301,*0401,*0601,*0604/5/6/7,*0302 in EH group were significantly higher than those in control group (P<0.01 or P<0.05).The frequencies of *0501,*0602,*0603/8,*0606,*0402,*0604/5/6/8 in EH group were significantly lower than those in control group (P<0.01 or P<0.05).Conclusion In Ningxia Hui population,allele DQB1*0301,*0401,*0601,*0604/5/6/7 and *0302 might be danger factors, while *0501,*0602,*0603/8,*0606,*0402 and *0604/5/6/8 might be resistive factors of EH.

Key words: HLA antigens;susceptibility;hypertension

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