关键词: 喹硫平；万拉法新；神经元损伤

Abstract:

To study the influence of quetiapine and venlafaxine in neuronal injury after cerebral ischemia and stress and illuminate the protective effects of quetiapine and venlafaxine after global cerebral ischemia and stress．Methods  Male ICR mice were pretreated with venlafaxine or quetiapine for 14 d.On the 15th day,the bilateral common carotid arteries of mice were occluded.This experiment was divided into sham group(Saline),sham plus stress group(Saline+Sham),ischemia plus stress group (Saline+ Ischemia+Stress),quetiapine plus ischemia plus stress group (QUE+Ischemia+Stress) and venlafaxine plus ischemia plus stress group (VEN+ Ischemia+Stress).The neuronal injury after cerebral ischemia  and stress was detected with immunohistochemical and Nissle  staining．Results Compared with sham group,the NeuN positive cells  were not significantly changed in sham plus stress group(P>0.05);compared with sham group or sham plus stress group,the NeuN positive cells were significantly decreased in ischemia plus stress group（P<0.05）；compared with ischemia plus stress group,the NeuN positive cells  were not significantly changed in venlafaxine plus ischemia plus stress group (P>0.05);compared with ischemia plus stress group,the NeuN positive cells were significantly increased in  quetiapine plus ischemia plus stress group（P<0.05）. Compared with sham group,the Nissle staining positive cells  were not significantly changed in sham plus stress group(P>0.05);compared with sham group or sham plus stress group,the Nissle staining positive cells were significantly decreased in ischemia plus stress group（P<0.05）；compared with ischemia plus stress group,the Nissle staining positive cells were not significantly changed in venlafaxine plus ischemia plus stress group (P>0.05);compared with ischemia plus stress group,the Nissle staining positive cells were significantly increased in quetiapine plus ischemia plus stress group（P<0.05）.Conclusion Quetiapine can attenuate the neuronal injury and has protective effects in mouse models after global cerebral ischemia and stress.

Key words: quetiapine；venlafaxine;neuronal injury