关键词: 三苦滴丸；正交实验；成型工艺

Abstract:

Objective To explore the conditions of preparation technology of Sanku dropping pills and provide the basis for further development of traditional Chinese medicine in treatment of  coronary heart disease and angina pectoris.  Methods Time limit of dissolution,weight variation and appearance(length pellets,hardness,color uniformity) were used as evaluation indexes of the test,the single factor investigation method was adopt to select the variety of the matrix and the dropping distance;on the basis of orthogonal test,the good dropping conditions about the proportion of two types of matrix，matrix with the medicine and the temperature of liquid medicine were selected.Results The best pill formatting process was that the dimethyl silicon oil was used as refrigerant,the ratio of PEG 4000 to PEG6000 was 1∶6,the ratio of medicine to matrix was 1∶2,the dripping temperature was 80℃,the dropping distance was 5 cm,the dropping speed was 18－20 drops·min^-1.Conclusion The optimized moulding process results is stable and feasible,suitable for mass production 

Key words: Sanku dropping pills;orthogonal test;preparation process