关键词: 苯系物；P16/CDKN2A蛋白；血细胞计数

Abstract:

Objective  Below the national health standards,to observe the changes of the blood cell count and P16 /CDKN2A protein content in plasma of workers who long-term exposed to benzene series,and to provide theoretical basis for better monitoring and supervision in benzene series pollution.Methods 50 workers which worked on operating environment more than 2 years were selected as exposed group in one printing plant in Shenzhen,and  50 administrative and logistic staffs in the same printing plant were used as control group.The inspections were taken on white blood cell count,red blood cell count,hemoglobin content and platelet count in
 two groups by blood routine examination.The plasma P16 /CDKN2A protein content in two groups were detected by ELISA assay.The concentrations of benzene,toluene and xylene in exposed group in the operating and non-operating environment were determined at the same time.Results The benzene,toluene and xylene levels in exposed and control groups were lower than the national health standards.The white blood cell count,red blood cell counts,hemoglobin contents and platelet counts in two groups were all in normal range and had no significant differences between two groups(P>0.05).The average content of plasma P16 /CDKN2A protein of the workers in the exposed group was lower than that in control group,but there was no significant difference between two groups(P>0.05).Conclusion  In the exposure condition,long-term exposure to low concentrations of benzene series has no significant effects on blood cell count and plasma P16 /CDKN2A protein content of the workers.