Journal of Jilin University(Medicine Edition) ›› 2021, Vol. 47 ›› Issue (6): 1455-1461.doi: 10.13481/j.1671-587X.20210615
• Research in basic medicine • Previous Articles Next Articles
Xin ZHANG,Chaojuan JU(),Xin JIN,Chaohui XIONG,Yan ZHAO
Received:
2020-09-04
Online:
2021-11-28
Published:
2021-12-14
Contact:
Chaojuan JU
E-mail:xinzh1978@163.com
CLC Number:
Xin ZHANG,Chaojuan JU,Xin JIN,Chaohui XIONG,Yan ZHAO. Protective effect of exogenous nerve growth factor on scleral tissue of guinea pigs with form-deprived myopia and its mechanism[J].Journal of Jilin University(Medicine Edition), 2021, 47(6): 1455-1461.
Tab. 1
D and axis lengths of eyes of guinea pigs in various groups"
Group | D | Axis length of eye (l/mm) | ||
---|---|---|---|---|
Right eye | Left eye | Right eye | Left eye | |
Control | 3.42±0.28 | 3.36±0.31 | 7.34±0.20 | 7.40±0.23 |
Model | 0.75±0.16* | 3.40±0.48 | 10.17±0.34* | 7.56±0.28 |
NGF | ||||
Low concentration | 1.60±0.50△ | 3.33±0.41 | 8.93±0.37△ | 7.50±0.22 |
High concentration | 2.21±0.62△# | 3.43±0.44 | 8.06±0.36△# | 7.44±0.30 |
Tab.2
Expression levels of GSK-3β, β-catenin, and VEGF mRNA in scleral tissue of guinea pigs in various groups"
Group | GSK-3β mRNA | β-catenin mRNA | VEGF mRNA |
---|---|---|---|
Control | 0.340±0.021 | 0.162±0.013 | 0.114±0.014 |
Model | 0.329±0.022 | 0.261±0.019* | 0.293±0.024* |
NGF | |||
Low concentration | 0.283±0.023△ | 0.359±0.033△ | 0.342±0.026△ |
High concentration | 0.215±0.020△# | 0.415±0.029△# | 0.387±0.033△# |
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