BCL6B基因的生物学功能及其在肿瘤发生发展中作用的研究进展

doi:10.13481/j.1671-587X.20260229

Abstract

Abstract:

B-cell chronic lymphocytic leukemia/lymphoma 6 member B （BCL6B） gene is a homolog of B-cell/lymphoma 6 （BCL6） and belongs to the zinc finger and BTB domain-containing protein （ZBTB） family， playing an important role in regulating gene expression and cell proliferation. The function of BCL6B in various cellular processes and its potential clinical applications have attracted widespread attention. The BCL6B protein participates in the formation of transcriptional repression complexes and regulates multiple key signaling pathways including Notch and p53. In various solid tumors including hepatocellular carcinoma， gastric cancer， colorectal cancer， and breast cancer， BCL6B expression is frequently downregulated due to promoter hypermethylation， functioning as a tumor suppressor gene involved in inhibiting cell proliferation， migration， and invasion， and inducing apoptosis and cell cycle arrest； its high expression in a few tumors such as differentiated thyroid carcinoma also suggests the complexity of its function. Given the close association between BCL6B expression and tumor progression as well as patient prognosis， BCL6B is considered a promising prognostic biomarker and epigenetic therapeutic target. This article systematically reviewed the gene and protein structures and biological functions of BCL6B， with a focus on its role in the occurrence and development of various tumors and the latest research progress on the related molecular mechanisms， aiming to provide new insights for the precision diagnosis and treatment of tumors.

Key words: BCL6B gene, Gene function, Regulatory mechanism, Biomarker, Neoplasm

CLC Number:

R730.2

Yuqing PAN,Jiayan TAN,Suqin WANG,Ya LI. Research progress in biological function of BCL6B gene and its role in occurrence and development of tumor[J].Journal of Jilin University(Medicine Edition), 2026, 52(2): 551-560.

Figures/Tables 2

References 42

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Research progress in biological function of BCL6B gene and its role in occurrence and development of tumor

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