IL-17E和IL-17F及其受体在结直肠癌组织中的表达及其意义

doi:10.13481/j.1671-587x.20180322

Abstract

Abstract: Objective: To explore the expressions of interleukin-17E(IL-17E),interleukin -17F(IL-17F) and their receptors interleukin -17RB(IL-17RB),interleukin -17RC(IL-17RC) in enteritis,intestinal polyps and colorectal carcinoma tissues,and to analyze their relationships with the malignancy of colorectal carcinoma. Methods: Immunohistochemistry staining was used to detect the expressions of IL-17E,IL-17RB,IL-17F, and IL-17RC in the tissues of enteritis (n=15),intestinal polyps (n=5) and colorectal carcinoma (n=30).The relationships between IL-17E and IL-17RB,IL-17F and IL-17RC,and the relationships between IL-17E,IL-17F and malignancy of colorectal carcinoma were analyzed. Results: IL-17E,IL-17F,IL-17RB and IL-17RC mainly expressed in glandular epithelial cells,mononuclear cells and vascular endothelial cells as well as partial carcinoma cells.The positive expression rates of IL-17E in enteritis and intestinal polyps tissues were higher than that in colorectal carcinoma tissue (P<0.05).Compared with enteritis tissue,the positive expression rates of IL-17F in intestinal polyps and colorectal carcinoma tissues were increased (P<0.05),which was increased with the increasing of malignancy of coloretal carcinoma.Compared with colorectal carcinoma tissue,the positive expression rates of IL-17RB in enteritis and intestinal polyps tissues were increased (P<0.05).Compared with enteritis and intestinal polyps tissues,the positive expression rate of IL-17RC in colorectal carcinoma tissue was increased (P<0.05).There was positive correlation between the positive expression rate of IL-17F and the positive expression rate of IL-17RC in colorectal carcinoma tissue(r=0.667,P=0.001). Conclusion: IL-17F,IL-17RC,IL-17E,and IL-17RB signals may take part in the incidence and progression of colorectal carcinoma.

Key words: colonrectal neoplasms, interleukin-17E, interleukin -17RC, interleukin -17RB, interleukin -17F

CLC Number:

R735.35

YANG Xueliang, SUN Xuemei, ZHAO Xiaohui, YANG Lijuan, SHEN Weigao, XIAO Zishen, GUO Chong, LIU Yanbo. Expressions of IL-17E, IL-17F and their receptors in colorectal carcinoma tissue and their significances[J].Journal of Jilin University Medicine Edition, 2018, 44(03): 574-578.

References

[1] 陈琼,刘志才,程兰平,等.2003-2007年中国结直肠癌发病与死亡分析[J].中国肿瘤,2012,21(3):179-182.
[2] Jess T,Rungoe C,Peyrin-Biroulet L.Risk of colorectal cancer in patients with ulcerative colitis:a meta-analysis of population-based cohort studies[J].Clin Gastroenterol Hepatol,2012,10(6):639-645.
[3] 杨学良,孙雪梅,赵晓晖,等.白细胞介素-17A及其受体与巨噬细胞在肠癌、肠炎和肠息肉组织中表达及意义[J].中国老年学杂志,2018,38(1):1-3.
[4] Tang W,Smith SG,Salter B,et al.Allergen-induced increases in interleukin-25 and interleukin-25 receptor expression in mature eosinophils from atopic asthmatics[J].Int Arch Allergy Immunol,2016,170(4):234-242.
[5] Song X,Qian Y.IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases[J].Cell Signal,2013,25(12):2335-2347.
[6] Cua DJ,Tato CM.Innate IL-17-producing cells:the sentinels of the immune system[J].Nat Rev Immunol,2010,10(7):479-489.
[7] De Luca A,Pariano M,Cellini B,et al.The IL-17F/IL-17RC axis promotes respiratory allergy in the proximal airways[J].Cell Rep,2017,20(7):1667-1680.
[8] Qian X,Chen H,Wu X,et al.Interleukin-17 acts as double-edged sword in anti-tumor immunity and tumorigenesis[J].Cytokine,2017,89(1):34-44.
[9] Gaffen SL.Recent advances in the IL-17 cytokine family[J].Curr Opin Immunol,2011,23(5):613-619.
[10] Ibrahim S,Girault A,Ohresser M,et al.Monoclonal antibodies targeting the IL-17/IL-17RA axis:an opportunity to improve the efficiency of anti-VEGF therapy in fighting metastatic colorectal cancer?[J].Clin Colorectal Cancer,2018,17(1):e109-e113.
[11] Liu Y,Zhao X,Sun X,et al.Expression of IL-17A,E,and F and their receptors in human prostatic cancer:Comparison with benign prostatic hyperplasia[J].Prostate,2015,75(16):1844-1856.
[12] Liu Y,Yang W,Zhao L,et al.Immune analysis of expression of IL-17 relative ligands and their receptors in bladder cancer:comparison with polyp and cystitis[J].BMC Immunol,2016,7(1):36.
[13] Wei L,Liu M,Xiong H,et al.Up-regulation of IL-23 expression in human dental pulp fibroblasts by IL-17 via activation of the NF-κB and MAPK pathways[J].Int Endod J,2017,6(10):1111.
[14] Iwakura Y,Ishigame H,Saijo S,et al.Functional specialization of interleukin-17 family members[J].Immunity,2011,34(2):149-162.
[15] Hu Z,Luo D,Wang D,et al.IL-17 activates the IL-6/STAT3 signal pathway in the proliferation of hepatitis B virus-related hepatocellular carcinoma[J].Cell Physiol Biochem,2017,43(6):2379-2390.
[16] Roland CL,Harken AH,Sarr MG,et al.ICAM-1 expression determines malignant potential of cancer[J].Surgery,2007,141(6):705-707.
[17] Xu M,Dong C.IL-25 in allergic inflammation[J].Immunol Rev,2017,278(1):185-191.
[18] Thelen TD,Green RM,Ziegler SF.Acute blockade of IL-25 in a colitis associated colon cancer model leads to increased tumor burden[J].Sci Rep,2016,6(5):25643.
[19] Gelaleti GB,Borin TF,Maschio-Signorini LB,et al.Efficacy of melatonin,IL-25 and siIL-17B in tumorigenesis-associated properties of breast cancer cell lines[J].Life Sci,2017,183(8):98-109.

Expressions of IL-17E, IL-17F and their receptors in colorectal carcinoma tissue and their significances

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 10

[1]	WANG Tinggang, XUE Feng, LI Yu, NIU Zhaojian, WANG Ye. Effects of miR-26a targeting HMGA1 gene on growth, invasion and migration of colon cancer cells [J]. Journal of Jilin University(Medicine Edition), 2018, 44(06): 1205-1211.
[2]	WANG Dan, LI Yifei, LI Chun, DONG Zhiheng, DONG Ying, GAI Xiaodong. Relationships between expressions of B7-H1 and B7-H4 and Foxp3⁺ regulated T-cell infiltration in colorectal cancer tissue [J]. Journal of Jilin University Medicine Edition, 2018, 44(03): 543-547.
[3]	CAO Yansha, LI Hua, CHEN Minghong, LIU Baoqin, WANG Huaqin, LI Ning. Expression of BAG3 protein in colon cancer tissue detected by tissue microarray method and its clinical significance [J]. Journal of Jilin University Medicine Edition, 2017, 43(06): 1177-1181.
[4]	SHI Junzhong, ZHUANG Jianbin, ZHANG Chuanshan, LIU Xianming, KONG Dalu. Expression of β-tubulin Ⅲ in colon adenocarcinoma tissue and its clinical significance [J]. Journal of Jilin University Medicine Edition, 2017, 43(04): 770-775.
[5]	ZHONG Hua, LIU Diqun. Expressions of COX-2 and Ki-67 in colorectal carcinoma tissue and theirclinical significances [J]. Journal of Jilin University Medicine Edition, 2016, 42(06): 1168-1172.
[6]	YAN Mengmeng, XU Shan, GAO Yan, LIU Yang, HE Mengzi, CHEN Silin, LI Pengwu, LIU Xiaodong, MA Shumei. Effect of miR-18a on irradiation sensitivity of colorectal cancer SW116 cells [J]. Journal of Jilin University Medicine Edition, 2015, 41(02): 240-244.
[7]	WANG Hai-li,LI Xiao-ying,HAN Xiao,AN Li-ping,GUAN Xiao-hui. Expressions of ASPP family in colorectal carcinoma tissue and their clinical significances [J]. Journal of Jilin University Medicine Edition, 2014, 40(03): 659-663.
[8]	ZHANG Xia,ZHANG Xiu-mei,XIAO Jian-ying. Inhibitory effect of siRNA targeting CK2α gene on growth of HCT116 cells and its mechanism [J]. Journal of Jilin University Medicine Edition, 2014, 40(03): 621-625.
[9]	LIU Shan-shan,YANG Yan,JIAO Ben-zheng,LI Wei. Effects of fluorouracil combined with wortmannin on proliferation and apoptosis in human colon cancer cells  [J]. Journal of Jilin University Medicine Edition, 2013, 39(1): 29-33.
[10]	. Influence of PTEN on proliferation of colon cancercell HCT-8 by siRNA [J]. J4, 2011, 37(2): 231-235.
[11]	CHEN Shu-Jun, LANG Xiao-Ou, ZHANG Chun-Yang, ZHANG Shao-Jun, JIANG Wen-Hua. Expressions of Skp2-P^27kip1 and apoptosis-related genes in colon carcinoma and significances [J]. J4, 2009, 35(3): 503-506.
[12]	WANG Bin,SONG Yan. Expression of osteopontin in colon cancer tissue and detection of osteopontin in serum [J]. J4, 2007, 33(2): 324-326.
[13]	CUI YA-nan，BO Li-hua， XUE Li-juan, YANG Shao-juan， BU Li-sha， GAO Shen. Effects of 5-Fu on apoptosis of human colon cancer cells and expressions of related genes [J]. J4, 2007, 33(1): 91-94.
[14]	JIANG Yang,SONG Yan, ZHANG Ying-chao, WU Guang-mou， ZHANG Guo-li， ZHU Ping. Influences of LHRH-PE40 on proliferation inhibition and apoptosis of human colon carcinoma cells [J]. J4, 2006, 32(4): 647-650.
[15]	CAO Hai-ping，SU Zhen-bo，ZHANG Gui-zhen. Expressions of decorin mRNA and protein in colorectal carcinoma [J]. J4, 2006, 32(2): 316-318.