According to the patients’ willing，eighty-six postmenopausal women with periodontitis were divided into minocycline hydrochloride group （observation group， n=43） and iodine glycerin group （control group， n=43）. The total effective rates of the patients in two groups were evaluated. The probing depth （PD）， plaque index （PLI）， and bleeding index （BI） of the patients in two groups were recorded and compared before treatment and 4 weeks after treatment. The levels of interleukin 6 （IL-6）， hypersensitive C-reactive protein （hs-CRP） and tumor necrosis factor-α （TNF-α） in gingival crevicular fluid of the patients in two groups before treatment and 4 weeks after treatment were measured by ELISA method and the levels of osteocalcin （OC） in gingival crevicular fluid of the patients in two groups were measured by electrochemiluminescence.

There were no significant differences in PD，PLI，BI and the levels of IL-6， hs-CRP， TNF-α and OC in gingival crevicular fluid of the patients in two groups before treatment （P>0.05）. Four weeks after treatment，PD，PLI，BI and the levels of IL-6， hs-CRP， TNF-α and OC in gingival crevicular fluid of the patients in two groups were significantly lower than those before treatment （P<0.05）； compared with control group， the total effective rate of the patients in observation group was significantly increased （P<0.05），PD， PLI and BI were significantly decreased（P<0.05），the levels of IL-6， hs-CRP，and TNF-α in gingival crevicular fluid were significantly decreased （P<0.05）， and the level of OC in gingival crevicular fluid decreased was significantly decreased（P<0.05）.

Minocycline hydrochloride has a significant effect on the treatment of postmenopausal women with periodontitis. It can improve the periodontal parameters.