NLRP3、AIM2和CASP1基因在慢性阻塞性肺疾病急性加重发病中的作用

doi:10.13481/j.1671-587x.20160126

Abstract

Abstract:

Objective: To study the expressions of NLRP3,AIM2,CASP1 genes and interleukin-1β (IL-1β),interleukin-18 (IL-18)in the patients with acute exacerbations of chronic obstructive pulmonary diseases (AECOPD),and to clarify their mechanisms.Methods: The sputum of patients with AECOPD (n=20)and controls (n=12)were collected,the expressions of NLRP3,AIM2 and CASP1 genes were determined by Real-Time fluorescent quantitative PCR in two groups. and the expressions of IL-1β and IL-18 in sputum supernatant were detected by ELISA. Results: Compared with control group,the expressions of NLRP3,AIM2 and CASP1 genes of the patients in AECOPD group were elevated by 3.83,1.70,2.42 times,respectively (P<0.05);the expression levels of IL-1β and IL-18 in sputum supernatant of the patients in AECOPD were increased significantly (P < 0.05).Conclusion: NLRP3 and AIM2 genes are involved in the pathological process of AECOPD.

Key words: acute exacerbation chronic obstructive pulmonary disease, NOD-like receptor protein 3, absent in melanoma 2, cysteinyl aspartate specific proteinase-1, innate immune

CLC Number:

R563

WANG Guoqiang, MU Jia, LI Yuan, YUAN Yuze, WANG Yubo, SONG Chenxue, XIE Jingshu, ZHENG Jingtong, WANG Fang. Influence of NLRP3,AIM2 and CASP1 genes in acute exacerbations of chronic obstructive pulmonary diseases[J].Journal of Jilin University Medicine Edition, 2016, 42(01): 130-133.

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Influence of NLRP3,AIM2 and CASP1 genes in acute exacerbations of chronic obstructive pulmonary diseases

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