The U118 MG cells were cultured in vitro and divided into control group（0 μmol·L^－1 UB） and different concentrations （20， 40， 80， 120， 160 and 200 μmol·L^－1） of UB groups. After cultured for 24， 48 and 72 h， the proliferation rates of U118 MG cells in various groups were detected by CCK-8 method.The U118 MG cells were divided into control group（0 μmol·L^－1 UB） and different concentrations （40， 80 and 120 μmol·L^－1） of UB groups，and clone formation experiment was used to detect the rates of clone formation of U118 MG cells in various groups； cell scratch healing test was used to detect the scratch healing rates of U118 MG cells in various groups； Transwell chamber assay was used to detect the percentages of invasion U118 MG cells in various groups； flow cytometry was used to detect the apoptotic rates of U118 MG cells and the percentages of U118 MG cells at different cell cycles in various groups； Western blotting method was used to detect the expression levels of Vimentin，epithelial adhesive protein（E-cadherin），B cell lymphoma-2（Bcl-2） ，and Bcl-2 related X protein（Bax） in the U118 MG cells in various groups.

The CCK-8 results showed that compared with control group， the proliferation rates of U118 MG cells in different concentrations of UB groups at 24， 48 and 72 h after treatment were decreased（P<0.01） in a dose and time-dependent manner. The clone formation experiment results showed that compared with control group， the rates of clone formation of U118 MG cells in 40， 80 and 120 μmol·L^－1 UB groups were decreased（P<0.01） in a dose-dependent manner.The cell scratch test results showed that compared with control group， the scratch healing rates of U118 MG cells in 40， 80 and 120 μmol·L^－1 UB groups at 24 and 48 h after treatment were significantly decreased（P<0.05 or P<0.01） in a dose-dependent manner.The Transwell chamber assay results showed that compared with control group， the percentages of invasion U118 MG cells in 40， 80 and 120 μmol·L^－1 UB groups were decreased significantly（P<0.05 or P<0.01） in a dose- dependent manner.The flow cytometry results showed that compared with control group， the apoptotic rates of U118 MG cells in 80 and 120 μmol·L^－1 UB groups were increased（P<0.05 or P<0.01） in a dose-dependent manner， and the percentages of U118 MG cells at G₂/M phase were increased （P<0.01）. The Western blotting results showed that compared with control group， the expression levels of Vimentin and Bcl-2 proteins in U118 MG cells in different concentrations of UB groups were decreased （P<0.05 or P<0.01），and the expression levels of E-cadherin and Bax proteins were increased （P<0.01）.

UB can inhibit the proliferation， migration and invasion of human GBM U118 MG cells， inhibit the expression of Bcl-2 protein， increase the expression of Bax protein， induce the apoptosis， and result in G₂/M phase arrest.