Abstract: Abstract:Objective  To approach the effectiveness and safety of zaleplon compared with zopiclone in treating  insomnia with Meta-analysis and to provide basis for their application in clinic.Methods Computer　search was performed using the Cochrane Central Register of Controlled Trial，Ovid-medline,PubMed,EMBASE,CNKI,WanFang,VIP，and the randomized controlled trials (RCTs) were collected,then the retrieved studies according to predefined inclusion and exclusion criteria were screened,the quality of included studies was evaluated and RevMan 5.1.2 software was used for Meta analysis. Results  A total of 315 articles were found and 15 of them were finally included.The evaluation of the effectiveness of  insomnia in treatment of insomnia  was performed with sleep disorders scale reduction rate,χ2=7.54，df=14，P=0.91，Z=1.21(P＝0.23）；95%CI 0.88［0.71，1.08］. Security side effects of drug safety scale was used to evaluate the security,χ2=9.71，df=14，P=0.78，Z=4.09(P<0.0001）；95%CI　0.66［0.54,0.81］.Conclusion Zaleplon has the same effectiveness as zopiclone in treating insomnia and less side effect in safety compared with zopiclone.

Key words: zaleplon, zopiclone, insomnia, Meta-analysis