The clinical materials of one patient with gallbladder SCC were collected， and the clinical features， diagnosis and treatment methods of gallbladder SCC were discussed combined with the related literature review.

The male patient aged 51 years old was admitted to hospital because of “upper abdominal pain with radiating pain in the lower back for more than half a month”. The abdominal CT results indicated the gallbladder mass. The liver artery and vein angiography CT examination results showed that the gallbladder neoplasm invaded the common bile duct with common bile duct and intrahepatic bile duct dilatation， multiple liver metastasis and retroperitoneal lymph node metastasis in hilar region. The tumor-associated antigen CA125 level was 65.2 U·mL^－1 and neuron-specific enolase （NSE） level was 23.5 μg·L^－1， and both the levels were increased.The patient underwent ultrasound-guided puncture biopsy of liver space-occupying lesions and was pathologically diagnosed as metastatic SCC. Combined with the medical history and clinical data， gallbladder SCC with liver and retroperitoneal lymph node metastasis was diagnosed.After diagnosis， the patient received 2 cycles of etoposide oral chemotherapy， 4 cycles of nedaplatin + etoposide（EP） intravenous chemotherapy rather than the surgical treatment.The re-examination of abdominal CT results revealed that the lesion was significantly reduced. The patient was currently in stable condition and was under close follow-up.

The clinical manifestations of gallbladder SCC are poorly specific and prone to distant metastasis. Pathological diagnosis and immunohistochemistry are the golden standards for the diagnosis of gallbladder SCC. In this case， the EP regimen of gallbladder SCC is effective and the tumor volume is significantly reduced. The patients with gallbladder SCC should be followed up regularly during the treatment process.