基于元分析的差异表达基因识别

›› 2012, Vol. 42 ›› Issue (05): 1262-1266.

基于元分析的差异表达基因识别

吴佳楠^1,2, 周春光^1,3, 刘桂霞^1,3, 沈薇¹, 郑明¹, 周柚^1,3

1. 吉林大学计算机科学与技术学院, 长春 130022;
2. 长春大学计算机科学与技术学院, 长春 130022;
3. 吉林大学符号计算与知识工程教育部重点实验室, 长春 130022

收稿日期:2011-08-23 出版日期:2012-09-01 发布日期:2012-09-01
通讯作者: 刘桂霞(1963-),女,教授.研究方向:计算智能和生物信息学.E-mail:liugx@jlu.edu.cn E-mail:liugx@jlu.edu.cn
基金资助:
国家自然科学基金项目(60873146, 60803052, 60973092, 60903097); 吉林省科技发展青年研究项目(201201139, 20090116, 20101589); 吉林大学研究生创新基金项目(20111062).

RSDM:A method to identify differentially expressed genes based on meta-analysis

WU Jia-nan^1,2, ZHOU Chun-guang^1,3, LIU Gui-xia^1,3, SHEN Wei¹, ZHENG Ming¹, ZHOU You^1,3

1. College of Computer Science and Technology, Jilin University, Changchun 130022, China;
2. College of Computer Science and Technology, Changchun University, Changchun 130022, China;
3. Symbolic Computation and Knowledge Engineering Laboratory of the Ministry of Education, Jilin University, Changchun 130022, China

Received:2011-08-23 Online:2012-09-01 Published:2012-09-01

摘要/Abstract

摘要： 针对传统差异表达基因识别方法不能处理异质性数据集以及分析结果偏差较大的问题,提出了一个基于元分析及标准差过滤技术的差异表达基因识别算法标准差排序分析(RSDM)。对来自于不同实验平台的数据进行整合分析,过滤掉伪差异表达基因PDEGs,并找出遗失的真正的差异表达基因TDEGs。经实验验证,算法简单有效。

关键词: 计算机应用, 生物信息学, 元分析, 差异表达基因识别, 基因芯片数据, 标准差

Abstract: Traditional methods of Differentially Expressed Genes (DEGs) analysis can not be used to deal with heterogeneous data sets that the analysis results are inconsistent usually. A new method, named Rank Standard Deviation Meta (RSDM) analysis, is proposed in this paper for detecting DEGs. The method is based on the meta-analysis and rank standard deviation filtering technology. The proposed method can detect True Differentially Expressed Genes (TDEGs) and filter Pseudo Differentially Expressed Genes (PDEGs), both TDEGs and PDEGs coming from experimental datasets. The experiment results show that the propose method is of high efficiency.

Key words: computer application, bioinformatics, meta-analysis, identification of differentially expressed genes, microarray data, standard deviation

中图分类号:

TP399

吴佳楠, 周春光, 刘桂霞, 沈薇, 郑明, 周柚. 基于元分析的差异表达基因识别[J]. , 2012, 42(05): 1262-1266.

WU Jia-nan, ZHOU Chun-guang, LIU Gui-xia, SHEN Wei, ZHENG Ming, ZHOU You. RSDM:A method to identify differentially expressed genes based on meta-analysis[J]. , 2012, 42(05): 1262-1266.

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