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• 基础研究 • 上一篇    下一篇

旋转磁场对小鼠脑组织单胺类神经递质代谢的影响

李晓林1,姚树仁2,付 妍3,吕遐令3*,唐笑年3   

  1. 1. 吉林大学基础医学院生物化学与分子生物学实验中心,吉林 长春130021;2. 吉林大学基础医学院人体解剖学教研室,吉林 长春130021;3. 吉林大学物理学院,吉林 长春130021
  • 收稿日期:2003-04-15 修回日期:1900-01-01 出版日期:2004-01-28 发布日期:2004-01-28
  • 通讯作者: 吕遐令

Effect of rotating magnetic field on metabolismof monoaminergic neurotransmitters in mice

LI Xiao-lin1, YAO Shu-ren2, FU Yan3,LU Xia-ling3*, TANG Xiao-nian3   

  1. 1. Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences, Jilin University,Changchun 130021,China;2. Department of Anatomy, Jilin University,Changchun 130021,China;3. College of Physics,Jilin University,Changchun 130021,China
  • Received:2003-04-15 Revised:1900-01-01 Online:2004-01-28 Published:2004-01-28
  • Contact: LU Xia-ling

摘要: 目的:研究旋转磁场对小鼠单胺类神经递质的影响。 方法:将健康昆明种老龄雌鼠随机分为实验组和对照组,每组16只,用转速为2 000 r•min-1,平均磁感应强度为0.09T的旋转磁场作用于实验组小鼠头部,每日曝磁30 min,连续15 d。对照组将旋磁体取出后,处理方法同实验组。15 d后用化学荧光法测定小鼠脑组织中单胺类神经递质的含量。 结果:实验组小鼠组织中NE、DA、5-HT、5-HIAA含量明显升高,与对照组比较差异有显著性(P<0.05)。 结论:一定强度且作用一定时间的旋转磁场,在一定程度上能提高生物体单胺类神经递质的含量,且具有延缓衰老的功能。

关键词: 分析, 去甲肾上腺素, 多巴胺, 分析, 血清素, 分析, 羟基吲哚乙酸, 分析, 脑, 代谢, 疾病模型, 动物

Abstract: Objective To study the effect of rotating magnetic field on metabolism of monoaminergic neurotransmitters in mice. Methods Healthy aging mice of Kunming species were divided into two groups randomly: experimental group and control group.The heads of experimental mice were treated with a rotating magnetic field at 2 000 r•min-1 and 0.09T for 30 min per day,lasted 15 days;Mice in control group were treated at the same way after the rotating magnet was taken out. Monoaminergic neurotransmitters were determined by chemical fluorescence technique 15 days later. Results Compared with control group,the concentration of NE,DA,5-HT and 5-HIAA increased apparently (P<0.05). Conclusion The rotating magnetic field in a certain intensity and lasting a certain time can increase the content of monoaminergic neurotransmitters in body at a certain extent and it can also inhibit the caducity.

Key words: norepinephrine, analysis, dopamine, analysis, seroronin, analysis, hydroxyindoleacetic acid, analysis, brain, metabolism, disease models, animal

中图分类号: 

  • Q189