Journal of Jilin University Medicine Edition ›› 2015, Vol. 41 ›› Issue (03): 612-618.doi: 10.13481/j.1671-587x.20150334

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Meta-analysis on curative effect of dextrose prolotherapy for knee oteoarthritis

YE Dongmei1, CHEN Chen2, LIN Ziwei3, XU Yiming1, BAI Yuehong1   

  1. 1. Department of Rehabilitation, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China;
    2. Department of Human Anatomy, School of Medical Science, Dalian University, Dalian 116021, China;
    3. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Shanghai 200072, China
  • Received:2014-08-30 Published:2015-08-01

Abstract:

Objective To investigate the curative effect of dextrose used in knee osteoarthritis (KOA) by applying a Meta-analysis, and to provide evidence for dextrose prolotherapy of KOA. Methods The literatures about the effect of dextrose prolotherapy in the treatment of KOA were retrieved from Pubmed/Medline, Scopus the and Cochrane Library.All the related literatures were checked and qualified in the method of evidence-based medicine.The improvement of pain, physical function, and stiffness relief were analyzed by RevMan 5.1 between dextrose group and control group. Results Five case-control studies with a total of 355 knees from 234 patients were included.Meta-analysis showed that dextrose prolotherapy had both short-term and long-term effects on the pain relief(short term:SMD =-1.45, 95% CI:-2.42--0.48, P=0.003;long-term:SMD =-2.20, 95% CI:-3.45--0.94, P=0.000 6) in addition to physical function(SMD =-2.00, 95% CI:-2.84--1.55, P<0.000 01). The stiffness improvement was not significant(SMD =-0.05, 95% CI:-1.02-0.03, P=0.07). Conclusion For KOA, the dextrose prolotherapy could improve the symptoms of pain and physical function.But further studies are needed to exam its effects on stiffness.

Key words: dextrose, prolotherapy, knee joint, osteoarthritis, Meta-analysis

CLC Number: 

  • R684