吉林大学学报(医学版) ›› 2024, Vol. 50 ›› Issue (5): 1400-1405.doi: 10.13481/j.1671-587X.20240525

• 临床研究 • 上一篇    

外周血淋巴细胞亚群与颈动脉粥样硬化发生的关联性分析

于佳园,赵娣,姜新,徐静,姜丽丽,姜宏宇()   

  1. 吉林大学第一医院体检中心,吉林 长春 130021
  • 收稿日期:2023-10-09 出版日期:2024-09-28 发布日期:2024-10-28
  • 通讯作者: 姜宏宇 E-mail:jiang_hy@jlu.edu.cn
  • 作者简介:于佳园(1993-),女,吉林省敦化市人,在读硕士研究生,主要从事动脉粥样硬化的早期预防和诊治方面的研究。
  • 基金资助:
    吉林省科技厅智慧健康管理科技创新项目(YDZJ202202CXJD041);吉林省财政厅医疗卫生人才专项项目(JLSWSRXZX2023-48)

Association analysis on peripheral blood lymphocyte subsets and occurrence of carotid atherosclerosis

Jiayuan YU,Di ZHAO,Xin JIANG,Jing XU,Lili JIANG,Hongyu JIANG()   

  1. Physical Examination Center,First Hospital,Jilin University,Changchun 130021,China
  • Received:2023-10-09 Online:2024-09-28 Published:2024-10-28
  • Contact: Hongyu JIANG E-mail:jiang_hy@jlu.edu.cn

摘要:

目的 分析外周血淋巴细胞亚群与颈动脉粥样硬化(CAS)发生的关联性,探讨CAS发生的危险因素,为CAS的风险预测和早期干预提供依据。 方法 按照纳入和排除标准选取419名体检者作为研究对象,行颈动脉超声检查和T淋巴细胞、B淋巴细胞及自然杀伤(NK)细胞亚群检测,根据颈动脉内中膜厚度(IMT)将研究对象分为颈动脉正常组(n=166)和CAS组(n=253),收集2组研究对象的基本资料和实验室检查指标,包括年龄、性别、血压、既往病史、吸烟史、用药史、血脂及T淋巴细胞、B淋巴细胞和NK细胞亚群百分率等,采用Logistic回归分析研究对象CAS发生的危险因素。 结果 单因素分析,与颈动脉正常组比较,CAS组患者年龄、高血压患病率、糖尿病患病率和吸烟率均升高(P<0.05),外周血中CD4+T淋巴细胞百分率、CD4+T淋巴细胞计数、CD4+/CD8+比值、CD16+CD56+NK细胞计数及低密度脂蛋白胆固醇(LDL-c)水平升高(P<0.05),CD8+T淋巴细胞百分率降低(P<0.05)。多因素Logistic回归分析,年龄(OR=1.112,95%CI:1.083~1.142,P<0.001)、吸烟(OR=1.997,95%CI:1.192~3.346,P=0.009)、LDL-c(OR=1.427,95%CI:1.017~2.001,P=0.039)和CD4+T淋巴细胞百分率(OR=1.044,95%CI:1.002~1.087,P=0.039)是CAS发生的独立危险因素。 结论 CD4+T淋巴细胞百分率与CAS发生有关联,是CAS的危险预测因素。

关键词: 动脉粥样硬化, 颈动脉粥样硬化, 危险因素, 自然杀伤细胞, 低密度脂蛋白胆固醇

Abstract:

Objective: To analyze the association between the peripheral blood lymphocyte subsets and the occurrence of carotid atherosclerosis (CAS) and discuss the risk factors of CAS, and to provide the basis for risk prediction and early intervention of CAS. Methods A total of 419 subjects were selected according to the inclusion and exclusion criteria.All the subjects underwent carotid ultrasonography, and the detection of T lymphocyte, B lymphocyte, and natural killer(NK) cell subsets were performed. According to the carotid artery intima-media thickness(IMT), the subjects were divided into normal carotid artery group (n=166) and CAS group (n=253). The basic data and laboratory inspection indexes of the subjects in two groups were collected, including age, gender, blood pressure, medical history, smoking history, medication history, blood lipids, and percentages of T lymphocyte, B lymphocyte, and NK cell subsets. The risk factors for the occurrence of CAS of the subjects were analyzed using Logistic regression analysis. Results The univariate analysis results showed that compared with normal carotid artery group, the age, morbidity rate of hypertension, morbidity rate of diabetes, and smoking rate of the subjects in CAS group were increased (P<0.05), and the percentages of CD4+ T lymphocytes, CD4+ T lymphocyte count, CD4+/CD8+ ratio, CD16+CD56+NK cell count, and low-density lipoprotein cholesterol (LDL-c) level in peripheral blood were increased (P<0.05), while the percentage of CD8+T lymphocyte was decreased (P<0.05). The multivariable Logistic regression analysis results showed that age (OR=1.112,95%CI:1.083-1.142, P<0.001), smoking (OR=1.997,95%CI:1.192-3.346, P=0.009),LDL-c (OR=1.427, 95%CI:1.017-2.001, P=0.039), and percentage of CD4+T lymphocyte(OR=1.044,95%CI:1.002-1.087,P=0.039) were the independent risk factors for the occurrence of CAS. Conclusion The percentage of CD4+ T lymphocyte is associated with the occurrence of CAS and it is a predictive risk factor for CAS.

Key words: Atherosclerosis, Carotid atherosclerosis, Risk factor, Natural killer cell, Low density lipoprotein cholesterol

中图分类号: 

  • R543.4