吉林大学学报(医学版) ›› 2024, Vol. 50 ›› Issue (4): 1173-1181.doi: 10.13481/j.1671-587X.20240434

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炎症标志物在冠状动脉粥样硬化性心脏病诊断和治疗中应用的研究进展

王晓雨,李冰(),刘国晖()   

  1. 吉林大学中日联谊医院心血管内科,吉林 长春 130033
  • 收稿日期:2022-12-11 出版日期:2024-07-28 发布日期:2024-08-01
  • 通讯作者: 李冰,刘国晖 E-mail:libing606419@jlu.edu.cn;liugh@jlu.edu.cn
  • 作者简介:王晓雨(1997-),女,内蒙古自治区鄂尔多斯市人,在读硕士研究生,主要从事心血管疾病临床和基础方面的研究。
  • 基金资助:
    吉林省卫健委卫生健康科技能力提升项目(3D5223733430)

Research progress in application of inflammatory markers in diagnosis and treatment of coronary heart disease

Xiaoyu WANG,Bing LI(),Guohui LIU()   

  1. Department of Cardiology,China-Japan Union Hospital,Jilin University,Changchun 130033,China
  • Received:2022-12-11 Online:2024-07-28 Published:2024-08-01
  • Contact: Bing LI,Guohui LIU E-mail:libing606419@jlu.edu.cn;liugh@jlu.edu.cn

摘要:

炎症反应贯穿了冠状动脉粥样硬化性心脏病(CHD)发病和进展的全过程,各种炎症细胞及炎症因子参与其中,并在一定程度上决定着冠状动脉粥样硬化斑块的稳定性和疾病的进展程度。脂蛋白(a)[Lp(a)]、C反应蛋白(CRP)、中性粒细胞、血小板和单核细胞通过诱导炎症因子、刺激炎性细胞和分泌活性物质等多种方式参与炎症反应,发挥促动脉粥样硬化的作用,而淋巴细胞作为重要的免疫细胞,是抗炎的指标。高密度脂蛋白胆固醇(HDL-C)则通过反向运输胆固醇,抑制炎症细胞聚集进而发挥抗动脉粥样硬化的作用。近年来由上述炎症相关指标组合成的新型炎症标志物与CHD的发病及进展关系密切,在CHD的诊断、治疗和预后判断中具有重要的指导意义。降低炎症反应仍是目前CHD研究的热点,现通过分析新型炎症标志物促CHD发展的机制,以及针对相关炎症标志物的治疗进展进行综述,以期为CHD的诊治提供帮助。

关键词: 动脉粥样硬化, 冠状动脉粥样硬化性心脏病, 炎症, 标志物

Abstract:

The inflammatory response runs through the entire process of the onset and progression of coronary atherosclerotic heart disease (CHD); various inflammatory cells and inflammatory factors are involved, and to a certain extent, determine the stability of coronary atherosclerotic plaques and the progression of the disease. Lipoprotein(a) [Lp(a)], C-reactive protein (CRP), neutrophils, platelets, and monocytes participate in the inflammatory response through various mechanisms such as inducing inflammatory factors, stimulating inflammatory cells, and secreting active substances, thus promoting the atherosclerosis. In contrast, the lymphocytes, as important immune cells, serve as the indicators of anti-inflammation. High-density lipoprotein cholesterol (HDL-C) exerts its anti-atherosclerotic effects by reversing cholesterol transport and inhibiting the aggregation of the inflammatory cells. In recent years, novel inflammatory markers composed of the aforementioned inflammation-related indicators have been closely related to the onset and progression of CHD and have significant guiding value in the diagnosis, treatment, and prognosis of CHD. Reducing inflammation remains a hotspot in current CHD research. The study analyzes the mechanism of promoting the CHD development by new inflammatory markers and reviews the therapeutic advancements targeting these relevant inflammatory markers, and provides the basis for the diagnosis and treatment of CHD.

Key words: Atherosclerosis, Coronary heart disease, Inflammation, Marker

中图分类号: 

  • R541.4