Journal of Jilin University(Medicine Edition) ›› 2022, Vol. 48 ›› Issue (6): 1481-1489.doi: 10.13481/j.1671-587X.20220614
• Research in basic medicine • Previous Articles Next Articles
Shuhua YU1(),Wei LIU1,Qianqian WU1,Dongwei YANG2
Received:
2022-01-27
Online:
2022-11-28
Published:
2022-12-07
Contact:
Shuhua YU
E-mail:zk1jfz@163.com
CLC Number:
Shuhua YU,Wei LIU,Qianqian WU,Dongwei YANG. Effect of crocetin on vascular endothelial dysfunction and atherosclerosis in spontaneously hypertensive rats and its ROCK/JNK signaling pathway mechanism[J].Journal of Jilin University(Medicine Edition), 2022, 48(6): 1481-1489.
Tab.1
Systolic blood pressure and diastolic blood pressure of rats in various groups (n=10,x±s,P/mmHg)"
Group | Systolic blood pressure | Diastolic blood pressure |
---|---|---|
Normal | 113.35±4.26 | 72.27±4.25 |
Model | 187.68±12.03* | 116.91±5.27* |
CR Low dose | 168.76±10.03△ | 108.17±4.63△ |
Medium dose | 137.93±8.11△# | 97.25±5.91△# |
High dose | 124.22±6.74△#○ | 82.78±4.02△#○ |
Tab.2
Blood lipid levels and AI of rats in various groups"
Group | TC[cB/(mmol·L-1)] | TG[cB/(mmol·L-1)] | LDL-c[cB/(mmol·L-1)] | HDL-c[cB/(mmol·L-1)] | AI |
---|---|---|---|---|---|
Normal | 1.08±0.11 | 0.62±0.06 | 0.76±0.05 | 0.94±0.08 | 0.13±0.03 |
Model | 2.25±0.16* | 1.48±0.09* | 2.33±0.15* | 0.44±0.05* | 4.08±0.57* |
CR Low dose | 2.07±0.12△ | 1.36±0.06△ | 2.18±0.08△ | 0.52±0.03△ | 2.87±0.39△ |
Medium dose | 1.78±0.10△# | 1.14±0.06△# | 1.77±0.09△# | 0.68±0.04△# | 1.59±0.18△# |
High dose | 1.42±0.09△#○ | 0.85±0.06△#○ | 1.32±0.10△#○ | 0.87±0.04△#○ | 0.62±0.09△#○ |
Tab.3
Serum activities of GSH-Px and levels of MDA, NO, ET-1,and TXB2 of rats in various groups"
Group | MDA[cB/(nmol·L-1)] | GSH-Px[cB/(μmol·L-1)] | NO[cB/(μmol·L-1)] | ET-1 [ρB/(ng·L-1)] | TXB2[ρB/(ng·L-1)] |
---|---|---|---|---|---|
Normal | 8.12±0.21 | 109.52±9.68 | 22.10±2.18 | 65.85±4.31 | 32.61±3.10 |
Model | 15.27±1.08* | 58.24±3.68* | 13.58±0.72* | 114.78±5.95* | 58.99±4.60* |
CR Low dose | 14.12±0.62△ | 65.09±4.03△ | 14.54±1.10△ | 103.70±5.64△ | 53.33±3.77△ |
Medium dose | 11.86±0.84△# | 78.39±6.20△# | 16.66±1.14△# | 87.86±6.96△# | 46.06±3.69△# |
High dose | 9.52±0.81△#○ | 98.67±7.51△#○ | 19.96±0.94△#○ | 72.46±4.69△#○ | 35.86±3.24△#○ |
Tab.4
Expression levels of ROCK1, ROCK2,and JNK mRNA in aorta tissue of rats in various groups"
Group | ROCK1 | ROCK2 | JNK |
---|---|---|---|
Normal | 1.00±0.01 | 1.01±0.01 | 1.02±0.01 |
Model | 5.87±0.54* | 4.88±0.59* | 4.72±0.54* |
CR Low dose | 5.26±0.32# | 3.95±0.24# | 4.11±0.26# |
Medium dose | 3.94±0.47△# | 2.89±0.21△# | 2.77±0.15△# |
High dose | 1.96±0.18△#○ | 1.71±0.34△#○ | 1.62±0.26△#○ |
Tab.5
Expressions levels of ROCK1, ROCK2, JNK,and p-JNK proteins in aorta tissue of rats in various groups"
Group | ROCK1 | ROCK2 | JNK | p-JNK |
---|---|---|---|---|
Normal | 0.09±0.02 | 0.18±0.03 | 0.38±0.03 | 0.16±0.02 |
Model | 0.64±0.05* | 0.65±0.05* | 0.92±0.04* | 0.53±0.05* |
CR Low dose | 0.54±0.05# | 0.57±0.03# | 0.86±0.04# | 0.42±0.05# |
Medium dose | 0.38±0.05△# | 0.41±0.02△# | 0.79±0.04△# | 0.37±0.03△# |
High dose | 0.19±0.03△#○ | 0.24±0.04△#○ | 0.58±0.04△#○ | 0.31±0.03△#○ |
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