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Absolute Bioavailability of Armillarisin A in Rats
WANG Yan,, WANG Zhonghua, LIU Mingyuan, DONG Lei, GU Jingkai
J4. 2008, 46 (01):
154-156.
To investigate the pharmacokinetic characteristics of Armillarisin A and its absolute bioavailability in rats, 1.44 mg and 0.9 mg of Armillarisin A were given via ig and iv to SD rats, respectively; the plasma concentration of Armillarisin A in rats was determined by LCMS/MS. After ig administration of Armillarisin A, the main pharmacokinetic parameters cmax, t1/2, AUC0~t were (58.33±23.41) μg/L, (155±043) h, (4187±754) h·(μg/L), respectively; After iv administration of Armillarisin A, the major pharmacokinetic parameters cmax, t1/2, AUC0~t were (825.25±92.13) μg/L, (0.75±0.35) h, (140.64±19.73) h·(μg/L),
respectively. The absolute bioavailability was 18.61% after correction of dosage.
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