The composite girder bridge with multi-cell corrugated steel web has been widely used in recent years, but there are some deficiencies in the corresponding specification and fine calculation methods. At present, the design mostly adopts the computational analytical method combining the spatial bar system model, plane beam grillage model and solid model. However, the spatial bar system model is short of the refinement analysis on the space effect, such as the shear lag effect, effective distribution width problem, and eccentric load factor problem etc. Due to the similarity of the plane beam grillage method in the equivalence principle, it can not accurately reflect the shearing stress distribution and local stress of the top and bottom plates of the box type composite beam. The solid model is very difficult to combine with the overall calculation. Moreover, the spatial grid model can achieve the refinement analysis, with the integrity of the analysis and the comprehensiveness of the stress checking calculation, and can make up the deficiency of the analytical method currently. Through the example verification of the solid model and spatial grid model, it can be seen that the calculation results for the stress and the displacement of two models are almost consistent, indicating the applicability and precision of the grid model.The real bridge analysis shows that the space grid model of multiple chamber box girder with corrugated steel webs can be calculated the web shear transverse distribution clearly, and the each web shear distribution rules of cable-stayed bridge at the key sections of side and mid span, so it can provide some suggestions for this kind of engineering design.