A full-size car interior model was simplified. Realizable k-ε turbulence model and TCM human body heat regulation model were chosen with a reasonable set of solar radiation boundary, then the air temperature, air velocity and air angle parameters were simulated under twelve working conditions. Combined with the overall thermal comfort index deviation AEGT, cooling load Q, velocity field and temperature field distribution, the effect laws of different parameters on the car interior airflow field were studied from the point of view of comfort and energy efficiency.